Innate and Acquired Cellular Immunity in Children with Familial Hypercholesterolemia Treated with Simvastatin.

The aim of this cross-sectional study was to assess the influence of simvastatin treatment in children with familial hypercholesterolemia (FH) on parameters of cellular immunity. Twenty-six children with FH were included, of which thirteen were treated with 10 mg simvastatin for at least 26 weeks, and thirteen were age- and sex-matched with a low-cholesterol diet only. Total WBC count and lipid profile were measured.

Transnasal endoscopic skull base surgery in the COVID-19 era: Recommendations for increasing the safety of the method.

Transnasal endoscopic skull base surgery (eSBS) has been adopted in recent years, in great part to replace the extended procedures required by external approaches. Though sometimes perceived as "minimally invasive", eSBS still necessitates extensive manipulations within the nose/paranasal sinuses. Furthermore, exposure of susceptible cerebral structures to light and heat emanated by the telescope should be considered to comprehensively evaluate the safety of the method.

Cardiac Surgery is Associated with Biomarker Evidence of Neuronal Damage.

Background: Anesthesia and surgery is commonly associated with central nervous system sequelae and cognitive symptoms, which may be caused by neuronal injury. Neuronal injury can be monitored by plasma concentrations of the neuronal biomarkers tau and neurofilament light protein (NFL). Currently, there are no studies examining whether neuronal injury varies between surgical procedures.

Association of antioxidants and vitamin D level with inflammation in children with atopic dermatitis.

Background: Changing the resources of vitamin D and antioxidant nutrients may affect the course of allergic diseases. The aim of the study was to investigate the association between CoQ10, vitamin D, retinol, and α-tocopherol serum levels and severity of atopic dermatitis (AD) in children.

Methods: Twenty-nine children with AD aged from 1 to 15 years were enrolled into the study.

Longitudinal observation of children with enhanced total serum IgE.

Background: Long-term studies on the evolution of elevated total IgE (tIgE) concentration are in demand.

Objective: To investigate the prevalence of allergic diseases and influential factors in children with high tIgE levels during a 5-year period.

Methods: Children with high tIgE levels (>100 IU/mL) were study subjects.

T-regulatory cells in severe atopic dermatitis: alterations related to cytokines and other lymphocyte subpopulations.

The changes in lymphocyte subpopulations in atopic dermatitis (AD) concern also T-regulatory cells. We investigated the expression of various surface receptors on CD3(+)CD4(+)CD25(high)FoxP3(+) T-regulatory cells and the activation CD28(+) receptor and the inhibitory CD152(+) receptor on helper/inducer as well as cytotoxic/suppressor T cells. Peripheral blood lymphocytes of 15 AD patients and 20 healthy subjects were analyzed by flow cytometry using monoclonal antibodies.

[Concentration of IL-10, IL-13 and IFN-gamma cytokines in supernatants of microcultured CD4+ and NK cells in patients with non-allergic bronchial asthma].

Unlabelled: THE AIM OF THIS STUDY was the evaluation of T lymphocytes and NK function in patients with non-allergic asthma.

Material And Methods: Three groups: patients with non-allergic asthma (n = 30), patients with non-allergic asthma with concomitant recurrent infections (n = 24) and group of healthy adult volunteers (n = 20) were examined. CD4+ and NK cells were isolated from peripheral blood by magnetic separation method.

Heart rate turbulence in children--age and heart rate relationships.

Heart rate turbulence (HRT) is a chronotropic response of the sinus heart rhythm to ventricular premature beat (VPB). Children show decreasing heart rate together with the maturation of the autonomic nervous system. The aim of the research was to assess the relationship between HRT parameters, age, and heart rate and time domain heart rate variability (HRV) parameters in healthy children.

CD80 and CD86 expression on LPS-stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma.

CD80 and CD86 seem to play an important role in the allergen-induced secretion of interleukin (IL)-5 and IL-13. Up to now, the expressions of CD80 (B7.1) and CD86 (B7.

[Blood pressure in neonates born from pregnancies complicated by diabetes].

Introduction: Diabetes is one of the most frequent metabolic disorders that may be influenced by and occur during pregnancy. Hypertension is frequently associated with a diabetes and, as well as diabetes, is considered to be one of the risk factors of the cardiovascular and the renal disease. Diabetes during a pregnancy may predispose fetus, and therefore neonate, to develop several metabolic abnormalities.