LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up.

Background: Anxiety disorders are a major public health burden with limited treatment options.

Aims: We investigated the long-term safety and efficacy of lysergic acid diethylamide (LSD)-assisted therapy in patients with anxiety with or without life-threatening illness.

Method: This study was an -planned long-term follow-up of an investigator-initiated, two-centre trial that used a double-blind, placebo-controlled, two-period, random-order, crossover design with two sessions with either oral LSD (200 μg) or placebo per period.