Role of Yoga in Distinctly Targeting Modifiable Risk Factors in Type 2 Diabetes to Improve Immuno-Metabolic Axis.

Modifiable and non-modifiable risk factors in Type 2 Diabetes (T2D) contribute to chronic inflammation characterized by elevated pro-inflammatory mediators and constitutively activated immune cells. Chronic inflammation in T2D leads to perturbations in metabolism, resulting in altered immuno-metabolic axis and further vascular complications. Hence, reducing inflammation by targeting modifiable risk factors such as adiposity, sedentary lifestyle and psychological stress in T2D may facilitate efficient clinical management.

Impact Of Spinal Flexion and Extension-Based Yoga Asanas on Autonomic Variables in Experienced Yogic Practitioners: Study Protocol for a Randomized Crossover Trial.

Background: The autonomic nervous system (ANS) is a complex network responsible for maintaining homeostasis. Yoga, as a traditional mind-body intervention, is known to modulate autonomic function in both healthy and clinical populations. However, the differential effects of forward versus backward-bending yoga asanas on autonomic parameters remain unexplored.

The mediating influence of serum Klotho levels and the KL-VS heterozygosity on telomere shortening in schizophrenia.

Schizophrenia (SZ) has a considerable contribution of accelerated aging, and exploration of the mechanistic underpinnings of telomere attrition, one of the core pathophysiological hallmarks of accelerated aging could boost the development of new avenues for intervention in SZ. The longevity protein Klotho (KL) is reported to regulate the expression of key factors like telomeric repeat-binding factor. We tested the cross-sectional association between KL levels, its longevity genetic variant KL-VS and telomere length in schizophrenia, including 240 patients and 243 healthy controls (HCs).

A Longitudinal Two-Armed Randomized Controlled Trial Protocol to Evaluate the Efficacy of Yoga on Progression of Disease in Early Parkinson's Disease.

Background: Numerous studies have shown that yoga can aid patients with Parkinson's disease (PD) in managing their motor function, functional mobility, balance, anxiety, and overall quality of life. However, most of the reported research either needed more power or evaluated the results during or after the intervention. Due to the long-standing nature of PD, there are still few longitudinal studies investigating the potential of yoga to decrease the progression of the disease.

A comprehensive review on the implications of Yogic/Sattvic diet in reducing inflammation in type 2 diabetes.

Chronic inflammation in type 2 diabetes (T2D), characterized by constitutively activated immune cells and elevated pro-inflammatory mediators along with hyperglycaemia and increased free fatty acids and branched chain amino acid levels, significantly alters the immuno-metabolic axis. Over the years, dietary intervention has been explored as an effective strategy for managing T2D. Evidence from experimental and clinical studies indicates that various diets, including Mediterranean, Nordic, Palaeolithic and ketogenic diets, increase insulin sensitivity, decrease gluconeogenesis, and adiposity, and exert anti-inflammatory effects, thus preserving immuno-metabolic homeostasis in individuals with T2D.

Associations Between Klotho Levels, Heterozygosity and Cognition in Schizophrenia.

Background And Hypothesis: The relationship between Klotho and cognitive dysfunction in schizophrenia has been scarcely explored, with a few paradoxical findings. Hence, we aimed to enhance our understanding by testing associations between the functional KL-VS gene variant and circulating protein levels.

Research Design: This case-control study included 239 healthy controls and 241 patients with schizophrenia, who were comprehensively characterized by neurocognitive tests and further subtyped into cognitive clusters; cognitively deficient (CD) and cognitively spared (CS), using -means cluster analysis.

Influence of High-frequency Yoga Breathing on States Changes in Gamma Oscillation.

Background: Yoga breathing has been shown to enhance neurocognitive function and positive emotions by increasing electrical power in several frequency bands and synchronizing interhemispheric brain waves. The current study examined the immediate impact of practicing (KBH) on the electrical activity of the brain.

Methods: Thirty-six individuals who met the inclusion and exclusion criteria and ranged in age from 18 to 25 were randomly assigned, 1:1, to the KBH ( = 18) and breath awareness (BAW) ( = 18) groups.

Integrated Yoga and Naturopathy Interventions to Modify Functional Disability in Patients With Spinal Cord Injury: A Randomized Controlled Trial.

Objective: This study aimed to evaluate the use of integrated yoga and naturopathy intervention to modify functional disability and improve independence in patients with spinal cord injury.

Materials And Methods: In this randomized controlled trial, 48 spinal cord injury patients receiving residential rehabilitation, aged between 23 and 57 years (37.9±11.

Yoga-based lifestyle intervention for healthy ageing in older adults: a two-armed, waitlist randomized controlled trial with multiple primary outcomes.

Yoga-based clinical research has shown considerable promise in varied ageing-related health outcomes in older adults. However, robust frameworks have yet to be used in intervention research to endorse yoga as a healthy ageing intervention to test the multidimensional construct of healthy ageing. This was an assessor-masked, randomized controlled trial conducted among 258 sedentary, community-dwelling older adults aged 60-80 years, randomly allocated to 26-week yoga-based intervention (YBI) (n = 132) or waitlist control (WLC) (n = 126).

Cerebral Haemodynamic Changes in Type 2 Diabetes Mellitus Following a Three-Month Yoga Intervention: A Randomized Controlled Trial.

Background and purpose Cerebral haemodynamics and cognitive performance may be adversely affected in type 2 diabetes mellitus (T2DM). Previous studies reported reduced cerebral blood flow (CBF) and altered cerebrovascular reactivity (CVR) in T2DM. Yoga, an ancient holistic health approach, is known to be beneficial for T2DM.

Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial.

Introduction: The recent development of robust indices to quantify biological aging, along with the dynamic epidemiological transitions of population aging generate the unmet need to examine the extent up to which potential interventions can delay, halt or temporarily modulate aging trajectories.

Methods And Analysis: The study is a two-armed, open label randomised controlled trial. We aim to recruit 166 subjects, aged 60-75 years from the residential communities and old age clubs in Bangalore city, India, who will undergo randomisation into intervention or control arms (1:1).

Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP): A Qualitative Study Exploring the Trial Team's Facilitators and Challenges in Conducting a Feasibility Trial in India.

Background: In India, around 77 million people are at high risk of developing type 2 diabetes mellitus (T2DM). Yoga interventions can be effective in preventing T2DM. We conducted a feasibility randomized controlled trial (RCT) in India, and the intervention was the Yoga Programme for T2DM Prevention (YOGA-DP).

Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India: A Multicenter Feasibility Randomized Controlled Trial.

Introduction: Many Indians are at high risk of type 2 diabetes mellitus (T2DM). The blood glucose level can be improved through a healthy lifestyle (such as physical activity and a healthy diet). Yoga can help in T2DM prevention, being a culturally appropriate approach to improving lifestyle.

Adjunct tele-yoga on clinical status at 14 days in hospitalized patients with mild and moderate COVID-19: A randomized control trial.

Background: The initial insights from the studies on COVID-19 had been disappointing, indicating the necessity of an aggravated search for alternative strategies. In this regard, the adjunct potential of yoga has been proposed for enhancing the effectiveness of the standard of care with respect to COVID-19 management. We tested whether a telemodel of yoga intervention could aid in better clinical management for hospitalized patients with mild-to-moderate COVID-19 when complemented with the standard of care.

Smart Instructor for Guiding and Correcting Postures in Real Time.

In recent days, is gaining more prominence and people all over the world have started to practice it. Performing with proper postures is beneficial. Hence, an instructor is required to monitor the correctness of postures.