Enhancing the predictive capability of magnetic resonance imaging using medical data-supervised cardiovascular flow simulations: A case study for analyzing patient-specific flow in the human aorta.

Background: Detailed hemodynamic parameters are essential for managing cardiovascular diseases, as they reveal blood flow dynamics that affect disease progression and treatment. However, even such advanced techniques as 4D Phase Contrast MRI face challenges in providing accurate, high-resolution data due to limitations in spatial and temporal resolution and image artifacts. Computational Fluid Dynamics (CFD) can estimate these parameters theoretically, but patient-specific accuracy may be compromised due to assumptions in boundary conditions and material properties.

Patient-specific prediction of arterial wall elasticity using medical image-informed in-silico simulations.

Limitations in clinical cardiovascular research have driven the development of advanced simulations for patient-specific insights into arterial elasticity. However, uncertainties in model inputs, data resolution, and parameter estimation can compromise accuracy. Our research aimed to provide reliable estimates of the arterial wall elasticity non-invasively, where direct clinical measurement is difficult.

Electrokinetics of Erosive Seepage through Deformable Porous Media.

Channelization and branching patterns frequently appear in porous structures as a result of fluid-flow-mediated erosion, which causes spatiotemporal changes in the medium. However, most studies on electrokinetic effects in porous media focus on the overall impact of the electric field on electrical double-layer formation in micropores and its influence on ionic transport, without addressing the spatiotemporal erosive characteristics and resulting porosity distribution. In this study, we explore the interplay between flow-induced shear stress and an external electric field on the dynamic evolution of porosity in deformable porous media using semi-analytical modeling.

Leveraging spreadsheet analysis tool for electrically actuated start-up flow of non-Newtonian fluid in small-scale systems.

In this article, we demonstrate the solution methodology of start-up electrokinetic flow of non-Newtonian fluids in a microfluidic channel having square cross-section using Spreadsheet analysis tool. In order to incorporate the rheology of the non-Newtonian fluids, we take into consideration the Ostwald-de Waele power law model. By making a comprehensive discussion on the implementation details of the discretized form of the transport equations in Spreadsheet analysis tool, and establishing the analytical solution for a special case of the start-up flow, we compare the results both during initial transience as well as in case of steady-state scenario.