Early application of nanocarbon suspension in gastric cancer patients enhances postoperative lymph node detection.

Background: This retrospective cohort study explores the association between the interval of nanocarbon application before surgery and the detection of postoperative lymph nodes in patients undergoing gastric cancer surgery.

Methods: This retrospective study included eligible patients diagnosed with T1-3NanyM0 gastric cancer at Fuzhou Traditional Chinese Medicine Hospital between March 1, 2020, and March 31, 2023, based on predefined inclusion criteria. Participants were grouped according to the timing of nanocarbon suspension application: either on the same day as surgery or at least 3 days prior.

Inhibition of hepatocellular carcinoma growth modulation of the miR-221/SOX11 axis by curcumin and berberine.

Hepatocellular carcinoma (HCC) is a fatal malignancy that has limited treatment options. This study focused on the potential therapeutic effects of curcumin (CUR) and berberine (BBR) on the miR-221/SRY-box transcription factor 11 (SOX11) axis in HCC. We investigated the combined effects of CUR and BBR on HEPG2 and Huh7 cell survival and miR-221 expression using Cell Counting Kit-8 assays and RT-qPCR, respectively.

Hydroxyethyl Starch Curcumin Enhances Antiproliferative Effect of Curcumin Against HepG2 Cells Apoptosis and Autophagy Induction.

It is well documented that curcumin (CUR), as a polyphenol molecule originated from turmeric, has many advantages such as antioxidative, anti-inflammatory, neuroprotective, and antitumor effects. However, because of its poor water solubility and low bioavailability, the biomedical applications of CUR are limited. So, in this study, we modified CUR with conjugation to a food-derived hydrophilic hydroxyethyl starch (HES) an ester linkage to fabricate the amphiphilic conjugate HES-CUR prior to self-assembling into uniform nanoparticles (HES-CUR NPs).