Late Onset Malignant Metastatic Transformation of Benign Pheochromocytoma.

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from adrenal medulla and extra-adrenal paraganglia. Metastatic pheochromocytomas, pose diagnostic and therapeutic challenges due to their atypical presentations and potential for malignant transformation years after primary tumor resection. We report a case of 61-year-old woman who presented with intermittent cough, shortness of breath, and elevated blood pressure 6 years after resection of primary adrenal pheochromocytoma.

Impact of Early Testing and Analysis of Germline Genetic Mutation in Patients with Breast Cancer: A Single Institution Experience.

Breast cancer is the most common cancer among women worldwide, with germline mutations in high-penetrance genes like BRCA1 and BRCA2, and moderate-penetrance genes such as CHEK2 and ATM contributing majorly to the onset of the same. Universal germline genetic testing offers an avenue to improve early identification and develop appropriate management guidelines. Our retrospective cohort study analyzed data from 525 newly diagnosed breast cancer patients at Mercy Hospital Fort Smith from January 2020 to December 2023.

Prevalence, trends, and outcomes of metabolically healthy obesity or overweight in stroke hospitalizations of elderly patients: A 2016-2019 US population analysis.

Introduction: Obesity and overweight have been associated with an increase in the risk of stroke and poor outcomes. Meanwhile, Metabolically healthy obesity and overweight (MHOO) trends are understudied in association with stroke. This study aims to analyze the MHO trends and outcomes concerning stroke.

Serum direct bilirubin as a prognostic marker for short-term ischemic stroke morbidity and mortality: Pooled analysis of cohort studies.

Objectives: Recent research on serum bilirubin's impact on stroke outcomes presents conflicting evidence. Higher bilirubin levels have been associated with both protective effects against ischemic stroke and increased risk of poor neurological recovery and higher mortality.

Materials And Methods: Systematic searching of the PubMed and SCOPUS databases from inception till April 2024 yielded 139 studies of which four were included for analysis.