Publications by authors named "Manak Singh"

Article Synopsis
  • The study investigates how anticoagulant and antiplatelet drugs affect blood loss during surgery for hip fractures in elderly patients.
  • More patients on antiplatelet drugs needed blood transfusions and experienced higher calculated blood loss compared to those who did not take these medications.
  • The findings suggest that elderly patients on warfarin or direct oral anticoagulants bleed less than those on antiplatelet drugs like aspirin, indicating that delaying surgery for anticoagulant management may not be necessary.
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Purpose: Existing literature is discrepant on the differences in blood loss and need for transfusion between short and long cephalomedullary nails used for extracapsular geriatric hip fractures. However, prior studies used the inaccurate estimated rather than the more accurate 'calculated' blood loss based on hematocrit dilution (Gibon in IO 37:735-739, 2013, Mercuriali in CMRO 13:465-478, 1996). This study sought to clarify whether use of short nails is associated with clinically meaningful reductions in calculated blood loss and resultant need for transfusion.

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Insulin-stimulated glucose uptake (GU) by skeletal muscle is enhanced several hours after acute exercise in rats with normal or reduced insulin sensitivity. Skeletal muscle is composed of multiple fiber types, but exercise's effect on fiber type-specific insulin-stimulated GU in insulin-resistant muscle was previously unknown. Male rats were fed a high-fat diet (HFD; 2 wk) and were either sedentary (SED) or exercised (2-h exercise).

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