Publications by authors named "Man-jun Li"
Article Synopsis
- Hepatitis B and schistosomiasis co-infections are common in Africa and Asia, potentially worsening HBV severity due to immune modulation from schistosome infections.
- Research shows that chronic Schistosoma japonicum infections weaken immune responses to hepatitis B vaccination in mice, resulting in lower antibody production.
- Treating with Praziquantel before vaccination can restore immune function and improve vaccine efficacy in those infected with schistosomiasis.
[Ageing down-modulates the immune responses to Schistosoma japonicum infection in mice].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
April 2011
Objective: To investigate the effect of ageing on the immune responses against Schistosoma japonicum infection in mice.
Methods: Female BALB/c mice were divided into young group (2 months) and old group (18 months), each composed of 8 mice. Each mouse was percutaneously infected with 40 +/- 1 S.
Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum.
Exp Parasitol
August 2011
Cimetidine (CIM), a histamine-2-receptor antagonist, has a long history of safe use in gastric acid-mediated gastrointestinal disorders. In this study, we used CIM, as an adjuvant, with pEGFP-Sj26 GST (the recombinant plasmid containing enhanced green fluorescent protein gene and the gene encoding 26 kDa glutathione S-transferase of Schistosoma japonicum) DNA vaccine to immunized mice and attempted to enhance the protective effect against S. japonicum.
View Article and Find Full Text PDFWe developed a novel immunomagnetic bead ELISA based on IgY (egg yolk immunoglobulin) for detection of circulating antigen (CA) in sera of mice infected with Schistosoma japonicum. The assay involved the use of chicken polyclonal antibodies IgY against soluble egg antigens (SEA) of S. japonicum as a capture antibody and anti-SEA mouse monoclonal antibody NP28-5B labeled horseradish peroxidase (HRP) as a detecting antibody.
View Article and Find Full Text PDF[Effect of MNNG on ornithine decarboxylase activity in cells from adult Schistosoma japonicum].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
June 2010
Objective: To observe the change of ornithine decarboxylase(ODC) activity in cells from adult Schistosoma japonicum after the cells were treated with N-Methyl-N-Nitro-N-Nitrosoguanidine (MNNG).
Methods: The cells were treated with MNNG at a concentration of 3 micrograms/ml for 48 hours after the cells being incubated for one week. The cells were then cultured with RPMI-1640 containing 10% calf serum.