Publications by authors named "Mako Shiratori"
Reduction of elastin in the skin causes various skin diseases as well as wrinkles and sagging with aging. Sialidase is a hydrolase that cleaves a sialic acid residue from sialoglycoconjugate. Cleavage of sialic acid from microfibrils by the sialidase isozyme Neu1 facilitates elastic fiber assembly.
View Article and Find Full Text PDFSialidase cleaves sialic acid residues from a sialoglycoconjugate: oligosaccharides, glycolipids and glycoproteins that contain sialic acid. Histochemical imaging of the mouse pancreas using a benzothiazolylphenol-based sialic acid derivative (BTP3-Neu5Ac), a highly sensitive histochemical imaging probe used to assess sialidase activity, showed that pancreatic islets have intense sialidase activity. The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA) remarkably enhances glutamate release from hippocampal neurons.
View Article and Find Full Text PDFArticle Synopsis
- Sialidase is crucial for long-term potentiation and spatial memory, facilitating the removal of sialic acids from cell surfaces in response to neural activity.
- Increased sialidase activity linked to high-K-induced depolarization and chemical stimulation indicates a shift in sialidase localization rather than increased expression.
- High-frequency stimulation in hippocampal slices shows immediate desialylation, suggesting that sialidase plays a key role in the neural processes underlying memory formation.