Publications by authors named "Majd Alkhatib"
Objective: The aim of this study was to investigate the relationship between the clinical and radiological characteristics of olfactory groove meningiomas (OGMs) and their molecular profiles.
Methods: The authors performed targeted next-generation and whole-genome sequencing in 123 OGM samples collected from 4 international institutions, focusing on known meningioma-driver genes. They compared the molecular data with the clinical and radiographic features of the tumors.
Objective: Peripheral nerve field stimulation (PNFS) is a neuromodulatory surgical treatment used to treat severe refractory trigeminal neuralgia. However, most studies have had comparatively short follow-up periods. Thus, the authors performed a long-term analysis of patients who had received PNFS for trigeminal neuralgia.
View Article and Find Full Text PDFPurpose: The study aims to examine the possible correlation between genomic alterations and preoperative olfactory function in patients with olfactory groove meningioma (OGM), due to the frequent presence of olfactory impairment.
Methods: We utilised next-generation sequencing to analyse samples from 22 individuals with OGM in order to detect driver mutations. Tumour morphology was assessed using preoperative imaging, whereas olfactory function was examined using Sniffin' Sticks.
Article Synopsis
- The study investigates the distribution of clinically actionable mutations in foramen magnum (FM) meningiomas, which are challenging to surgically treat and have high risks associated with them.
- Targeted next-generation sequencing was performed on 62 FM meningiomas, excluding those related to radiation or neurofibromatosis type 2, and various patient and tumor characteristics were evaluated.
- Results showed that 93.5% of tumors had significant driver mutations, with TRAF7 and AKT1E17K being the most common, and their mutations were linked to specific tumor locations relative to the brainstem.