Unraveling the therapeutic landscape of miRNAs in pancreatic cancer.

Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), remains one of the deadliest malignancies with a dismal prognosis due to late diagnosis and limited effective treatments. This review explores the multifaceted role of circulating and exosomal microRNAs (miRNAs) in pancreatic cancer progression, metastasis, diagnosis, prognosis, and therapeutic potential. miRNAs-a class of small non-coding RNAs-regulate gene expression post-transcriptionally, influencing key oncogenic and tumor-suppressor pathways.