Publications by authors named "Mahesh Prakash Bhatta"
Article Synopsis
- Adipogenesis, the process of fat cell formation, involves significant changes in gene expression and cell structure, but current methods for analyzing live cell images are limited.
- Researchers used holotomography, a non-invasive imaging technique, to identify distinct markers of each stage in the transformation of stem cells from human umbilical cords into fat cells, revealing specific changes in cell shape and lipid droplet characteristics.
- The findings indicate clear morphological differences between preadipocytes, immature, and mature adipocytes, showing potential for advancing medical treatment strategies for metabolic diseases through better understanding of fat cell development.
Molecular mechanism of the anti-inflammatory and skin protective effects of in human skin keratinocytes.
Food Sci Biotechnol
February 2024
Unlabelled: Irradiation injury, especially caused by UVB, of the skin is one of the critical reasons for skin inflammation and damage. The present study aimed to explore the protective effect of leafy extract (SFLE) and its mechanism of action against UVB-induced damages of human keratinocytes. In this study, SFLE was prepared from 100 kg dried leaves using industrial-scale processes.
View Article and Find Full Text PDFDouble-strand RNA(dsRNA), which can induce inflammation, can be generated by necrotic keratinocytes in the skin environment. As an analog of dsRNA, polyinosinic-polycytidylic acid (poly(I:C)) is used to induce inflammation via the Toll-like Receptor 3 (TLR3) signaling pathway. Inotodiol, isolated from Inonotus obliquus, known as Chaga mushroom, is a natural lanostane-type triterpenoid with significant pharmacological activity and notable anti-inflammatory effects.
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