Clinical Assessment of Hypothyroid Patients Using the Zulewski Score and the Correlation Between Thyroid and Lipid Parameters: A Tertiary Care Centre-Based Study From Central India.

Introduction: Clinical scores based on signs and symptoms have been used in thyroidology to identify individuals at high risk for hypothyroidism. The current study observes the signs and symptoms of patients with hypothyroidism who are positive for hypothyroidism according to the Zulewski clinical score, and determines associations between thyroid and lipid profiles.

Methods: The current prospective cohort study was conducted among newly diagnosed hypothyroid patients aged 18-65 years with a Zulewski score > 5 (indicative of hypothyroidism) and biochemically diagnosed as hypothyroid.

A critical evaluation of available explicit deprescribing tools for their applicability to Indian elderly patients: a scoping review protocol.

Background: Among the elderly, who are often exposed to polypharmacy, explicit deprescribing tools offer clear, validated guidelines for safely reducing medications. However, the effectiveness of these tools varies across healthcare settings and populations. In India, unique sociocultural and healthcare challenges demand a tailored approach to deprescribing for elderly patients, and the need to adapt existing tools to local contexts.

Therapeutic Branding: A Common and Bizarre Practice That Scars for Life.

Introduction: Branding of skin in a living person is an ancient practice, was used to indicate ownership, as a membership of a cult, as a method of punishment, and even for public humiliation. While the above uses of branding are on a decline, we have come across numerous instances of the use of branding as a therapeutic measure. These archaic practices exacerbate the original illness and lead to complications such as secondary infection, scars, and keloid formation.

Magnitude and Predictors of Subclinical Hypothyroidism in Individuals With Impaired Glucose Tolerance.

Background: The screening for thyroid function abnormalities in asymptomatic individuals remains a topic of debate. The impact of subclinical hypothyroidism (SCH) on glucose metabolism has been less extensively researched. Our study aimed to assess the feasibility of thyroid-stimulating hormone (TSH)-based screening and evaluate the prevalence of SCH among individuals with impaired glucose tolerance (IGT) in a community-based setting.

The Prevalence and Determinants of Long-Term Glycemic Control Based on Serial Glycosylated Haemoglobin Values in Type 2 Diabetes Mellitus.

Introduction: Diabetes mellitus has become a significant public health issue in India, with a considerable proportion of the population living with the condition. Type 2 Diabetes Mellitus (T2DM), commonly linked with obesity, is associated with metabolic abnormalities and vascular complications. Effective long-term glycemic control is important in preventing complications and improving patient outcomes.

Shifting Priorities in Emergency Medicine: The Rise of Hematological and Hepatological Emergencies and Their Impact on Mortality Rates.

Background Liver disease is a major global health concern, causing millions of deaths each year. Cirrhosis, a serious complication of liver disease, is a leading cause of disability and healthcare costs. Alcohol abuse is a major contributor to liver diseases, particularly in high-income countries.

Outcome of COVID-19 infection in patients on antihypertensives: A cross-sectional study.

Background: Patients with coronavirus disease 2019 (COVID-19) infection frequently have hypertension as a co-morbidity, which is linked to adverse outcomes. Antihypertensives may affect the outcome of COVID-19 infection.

Aim: To assess the effects of antihypertensive agents on the outcomes of COVID-19 infection.

Case Report: Dengue Fever Progressing to Acute Liver Failure and Hepatic Encephalopathy.

Dengue fever is an important arboviral disease that significantly impacts the disease burden among populations residing in tropical regions. Dengue infection is known to have a broad spectrum of clinical manifestations, which range from fatal, life-threatening shock, encephalitis, and myocarditis to asymptomatic illness. Mild hepatic dysfunction with deranged hepatic laboratory parameters is a known entity with dengue fever.

Cytological Perspective in a Case of Doege-Potter Syndrome With Hypoinsulinemic Hypoglycemia.

Solitary fibrous tumor (SFT) of the lung is a rare mesenchymal neoplasm of uncertain histogenesis, unknown molecular features, and unpredictable clinical behavior, characterized by NAB2-STAT6 fusion. Hypoglycemia accompanying SFT (Doege-Potter syndrome) is an uncommon presentation. We present the cytomorphological features on biopsy imprint smears of a histopathologically confirmed case of SFT of the lung with an uncommon presentation.

Adult tetanus is not gone yet, but could be ready to leave: A case-series from central India.

Introduction: Adult tetanus is a neurotoxin mediated infectious disease, that continues to be seen despite availability of a highly efficacious vaccine. In India population-based burden estimates for adult tetanus are not available. Elimination of neonatal and maternal tetanus from India was achieved in 2015 with DPT (diphtheria, pertusis, and tetanus) vaccine during childhood and tetanus toxoid (TT) during antenatal care.

Iron Deficiency Anemia Presenting With Pancytopenia: A Study From India.

Introduction: Iron deficiency anemia (IDA) is the most common cause of anemia worldwide. IDA is commonly associated with thrombocytosis and normal or slightly decreased leukocyte count. Sometimes it can present with thrombocytopenia, but rarely present with pancytopenia.

Melioidosis as a Mystique Infection: A Study From Central India.

Introduction: Melioidosis is caused by the Gram-negative bacilli Burkholderia pseudomallei, which is found in contaminated water and soil and spreads via inhalation, inoculation, and ingestion. Melioidosis manifests diversely in immunocompetent and immunocompromised patients, ranging from asymptomatic to life-threatening respiratory distress, septic shock, localized tissue infection, necrotizing pneumonia, and soft organ abscesses.  Methods: An 18-month observational study was conducted at a tertiary center in central India among various confirmed melioidosis cases, with data gathered and analyzed.

Takayasu arteritis, an atypical presentation as chronic kidney disease.

Takayasu arteritis, also known as "pulseless disease" usually affects major vessels like aorta and its branches, pulmonary arteries, and renal arteries. Hypertension is the common presentation. Chronic kidney disease involvement is less common.

Case Report: Lepromatous Leprosy Masquerading as Acute Suppurative Lymphadenitis.

Leprosy is a chronic cutaneous infection. It is usually characterized by thickened nerves and maculo-anesthetic patches. Leprosy often has an unusual presentation, which is a diagnostic challenge.

The evaluation of serum lipid profile in chronic Hepatitis B patients at a Tertiary Care Centre in Western India: A cross-sectional study.

Introduction: Hepatitis B virus (HBV) is known as a metabolovirus due to its impact on lipid and glucose metabolism in the liver. Previous literature showed a trend of hypolipidemia and reduced risk of metabolic syndrome in hepatitis B surface antigen-positive patients. However, data from the Indian population are lacking.

Severe Autoimmune Hemolytic Anemia Complicating Treatment-naive Chronic Hepatitis C Infection: A Case Report.

Background: Haematological manifestations in Hepatitis C virus (HCV) infection have been uncommon since the advent of direct-acting antiviral drugs (DAAs). However, primary HCV infection can cause significant haematological disease in the form of various autoimmune cytopenias.

Case Presentation: We herein discuss a 68-years-old female with chronic HCV infection for the last 15 years (not on the treatment), who presented with complaints of progressive fatigue, exertional dyspnea, and increased abdominal distention over the previous 20 days.

Association of Inflammatory Markers with COVID-19 Outcome among Hospitalized Patients: Experience from a Tertiary Healthcare Center in Western India.

COVID-19 is a highly infectious disease and varies in the severity of presentation as well as survival outcome due to varied inflammatory responses. Hence, the present study is aimed to evaluate the role of inflammatory markers in predicting the outcome of COVID-19 in hospitalized patients. A total of 272 confirmed COVID-19 patients were included in the study.

Viral Ribonucleic Acid Shedding and Transmission Potential of Asymptomatic and Paucisymptomatic Coronavirus Disease 2019 Patients.

We studied the pattern and duration of viral ribonucleic acid (RNA) shedding in 32 asymptomatic and 11 paucisymptomatic coronavirus disease 2019 cases. Viral RNA shedding in exhaled breath progressively diminished and became negative after 6 days of a positive reverse-transcription polymerase chain reaction test. Therefore, the duration of isolation can be minimized to 6 days.

Concurrent acute myositis and Guillain-Barre syndrome in Cytomegalovirus infection - a rare case report.

Background: Cytomegalovirus (CMV) is a double stranded DNA virus and ubiquitous in nature. Association of Guillain-Barre syndrome (GBS) and CMV is well known but CMV acute myositis is a rare condition. Restriction of movements of limbs due to severe pain in myositis may obscure the diagnosis of GBS and this may easily miss.

Diagnosis and Management of Cryptogenic Occupational Tetanus: A Case Report from Rajasthan, India.

The reported cases of non-neonatal tetanus have doubled from 2015 to 2017 in India, while neonatal tetanus has declined by half during this period. Most of these non- neonatal tetanus are acquired by occupational exposure especially in high risk populations such as agricultural workers, industrial workers and health care workers secondary to increased spore exposure or risk for minor injuries. We report a case of occupational tetanus in a steel worker and discuss the importance of recognising tetanus as an occupational hazard and address issues related to its early diagnosis and management.

Bacteriological Profile and Antibiotic Resistance in Patients with Urinary Tract Infection in Tertiary Care Teaching Hospital in Western Rajasthan India.

Urinary tract infection (UTI) is one of the most common bacterial infection with a significant economic burden on the health care system in developing countries like India. Rising antibiotic resistance is a matter of great concern. ; Aims: The aim of this study was to determine the bacteriological profile and antibiotic resistance pattern in patients with UTI in Tertiary Care Hospital in western Rajasthan India.

Hyperhomocysteinemia in a Patient with Moyamoya Disease.

Moyamoya disease is a chronic progressive cerebrovascular disease characterized by bilateral occlusion or stenosis of arteries around circle of Willis. We report a case of 18-year-old female presented with recurrent episodes of headache and vertigo. On cerebral angiography, the patient was diagnosed to have moyamoya disease.