Publications by authors named "Magdalena Class"
Introduction: Durability of immune protection against reinfection with SARS-CoV-2 remains enigmatic, especially in the pediatric population and in the context of immune-evading variants of concern. Obviously, this knowledge is required for measures to contain the spread of infection and in selecting rational preventive measures.
Methods: Here, we investigated the serum neutralization capacity of 36 seropositive adults and 34 children approximately one year after infection with the ancestral Wuhan strain of SARS-CoV-2 by using a pseudovirus neutralization assay.
Article Synopsis
- The immune response to COVID-19 varies between children and adults, with children showing a unique plasmablast-driven initial response after mild or asymptomatic infections.
- Four months post-infection, children exhibit an enhanced antibody response, but lower B and T cell responses compared to adults, while overall neutralizing antibody effectiveness improves in both groups.
- After one year, children show signs of immune maturation, including increased S1-specific IgA and T cell development, indicating the potential benefit of booster vaccinations to strengthen their immune memory.