Publications by authors named "Mabel B Lee"
Background: In 2012, oocyte cryopreservation was no longer deemed experimental by the American Society of Reproductive Medicine. Since then, awareness and utilization of planned oocyte cryopreservation has become much more widespread. However, little is known regarding current national trends and the rate of warming and utilization of cryopreserved oocytes.
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- The study aimed to assess and compare aneuploidy rates and the chances of obtaining usable embryos in IVF cycles that used both preimplantation genetic testing for monogenic disorders (PGT-M) and aneuploidy (PGT-A) versus those that used PGT-A alone.
- Conducted as a retrospective cohort study, it analyzed 72,522 IVF cycles from patients aged 18-45 over a period from November 2019 to March 2023 at a single genetics laboratory.
- Results indicated that although the PGT-M+PGT-A group had a higher percentage of younger patients, there were no significant differences in aneuploidy rates between the two groups; however, PGT
Ribonucleotide reductase small subunit B (RRM2B) is a stress response protein that protects normal human fibroblasts from oxidative stress. However, the underlying mechanism that governs this function is not entirely understood. To identify factors that interact with RRM2B and mediate anti-oxidation function, large-scale purification of human Flag-tagged RRM2B complexes was performed.
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