Neuroprotective Agents With Reperfusion Therapies in Ischemic Stroke: Evidence From Recent Randomized Trials.

This systematic review evaluates the effectiveness and safety of adjunctive neuroprotective therapies administered in combination with reperfusion treatments, either intravenous (IV) thrombolysis, mechanical thrombectomy, or both, in adult patients with acute ischemic stroke (AIS). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search of four major databases was conducted with filters applied to include English-language randomized controlled trials (RCTs) published within the last five years. From an initial 622 records, 10 eligible RCTs were identified and analyzed.

Spatial assessment of heavy metal contamination in groundwater in the Kadaladi region, Tamil Nadu, India.

Groundwater quality in Kadaladi is a critical concern due to contamination from natural and human activities. This study assesses heavy metal concentrations across pre-monsoon and post-monsoon seasons at 44 sampling sites, using the Heavy Metal Pollution Index (HPI), Metal Index (MI), and non-carcinogenic risk (HQ) assessments. Key heavy metals analysed include Cu, Pb, Zn, Ni, Cd, Mn, and Fe, in Pre-monsoon and Post-monsoon with comparisons to WHO (2017) standards using atomic absorption spectrometry.

Collagen Type 1 Alpha 1 Chain as a Potential Therapeutic Target Shared Among Subtypes of Head and Neck Squamous Cell Carcinoma: Quantum Chemical Modeling of Bleomycin for Anticancer Drug Repurposing.

Head and neck squamous cell carcinoma (HNSCC) displays significant molecular heterogeneity, which hinders effective and safe treatments and clinical outcomes. This predicament also points to the need for an individually tailored personalized/precision medicine approach in HNSCC that includes the oral, hypopharyngeal, nasopharyngeal, and laryngeal subtypes. This study, with the overarching aim of personalized/precision medicine, attempted to identify (1) a molecular target shared by the HNSCC subtypes and (2) screen for potential anticancer drugs for repurposing that may work across the HNSCC subtypes.

Comparative Evaluation of Hardness in Ceramic Reinforced, Resin Modified Glass Ionomer Cement and Conventional Glass Ionomer Cement.

Aim And Background: This study compares the hardness of ceramic-reinforced glass ionomer cement (Amalgomer CR), resin-modified glass ionomer cement (RMGIC), and conventional glass ionomer cement (GIC) using Vicker's microhardness tester.

Materials And Methods: Nine disc-shaped specimens (5mm diameter, 2mm thickness) were prepared from three materials: Group A (GIC), Group B (Amalgomer CR), and Group C (RMGIC). Hardness was tested after 24 hours of storage at room temperature.

Fused pyrido[3,4-D]pyrimidine moiety with phthalazinone ring accelerate dual inhibition of PARP1 and CDK4 in triple-negative breast cancer: a hybrid design with computational investigation through molecular modeling and quantum mechanics.

Context: The PARP inhibitor olaparib is effective in breast cancer patients; however, its efficacy is reduced in triple-negative breast cancer (TNBC) due to mechanisms of drug resistance. Recent studies demonstrate that the CDK4 inhibitor palbociclib can enhance the sensitivity of cancer cells to PARP inhibitors. We designed 43 hybrid compounds by combining the pyrido[3,4-d]pyrimidine moiety from palbociclib with the phthalazinone ring from olaparib.