Formosulfathiazole: A Structural Revision.

Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.

Umbilical Cord Tensile Strength Under Varying Strain Rates.

The tensile strength of the umbilical cord (UC) is influenced by its composition-including collagen, elastin, and hyaluronan-contributing to its unique biomechanical properties. This experimental in vitro study aimed to evaluate the UC's mechanical behavior under varying strain rates and to characterize its viscoelastic response. Twenty-nine UC specimens, each 40 mm in length, were subjected to uniaxial tensile testing and randomly assigned to three traction speed groups: Group A ( = 10) at 8 mm/min, Group B ( = 7) at 12 mm/min, and Group C ( = 12) at 16 mm/min.

Clinical and Microbiological Study on Local Application of an Ozonated Olive Oil Gel in the Periodontal Pockets: A Randomized Double-Blind Trial.

: This study aims to evaluate the clinical and microbiological efficacy of a novel Activated Ozonated Extra-Virgin Olive Oil (AOEOO) gel as a topical adjunct in the treatment of periodontal pockets. : In this double-blind, randomized clinical trial, patients diagnosed with stage II-IV periodontitis received either scaling and root planing (SRP) and placebo gel or SRP combined with subgingival AOEOO gel application (test group). Periodontal indices-probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BOP)-were measured at baseline, 3, and 6 months.

V600E mutation associated with papillary high-grade serous ovarian cystadenocarcinoma in a 22q11.2DS patient.

Objective: Ovarian cancers exhibit very heterogeneous genetic and genomic aberrations with various pathogenetic and prognostic values. Chromosome 22 abnormalities, including del(22q) and duplications, are genetic multisystemic disorders, most commonly affecting cardiovascular, immune, and gastrointestinal systems, while tumors are rarely reported.

Methods: In this case report, we described a patient with 22q11.

Comparison of Different Microalgae Biomass Typologies Used in Rotifers Enrichment for Zebrafish () Larvae Nutrition.

The use of enriched rotifers with industrially produced microalgae represents a valuable tool for the enhancement of zebrafish larval nutrition and increased biological performance. Currently, a monoculture of microalgal species ( sp.) in form of liquid paste is routinely used for rotifers enrichment for zebrafish larvae feeding; however, the most adequate typology (i.