Improving Communication and Management Following a Positive Home HPV Self-Sampling Result: Comparing Intervention Strategies Between the HOME and STEP Trials.

Background: Mailed human papillomavirus (HPV) self-sampling kits improve cervical cancer screening adherence. The HOME trial found information needs and anxiety among HPV-positive patients. We designed a STEP trial to test optimized intervention strategies with bolstered educational materials and a centralized nurse communicating positive results.

Ag(I)-Catalyzed Heterocyclization/[3 + 2] Cycloaddition of α-Alkynylenones with β-Enaminones: Tandem Access to Highly Substituted Cyclopenta[]furans.

A robust Ag(I)-catalyzed tandem heterocyclization/[3 + 2] cycloaddition of α-alkynylenones with β-enaminones was developed, enabling efficient synthesis of cyclopenta[]furans with good yields, operational simplicity, and broad substrate scope. In addition, it also presents an extended methodology to synthesize unsymmetrical tri(hetero)aryl methane having chromone and furan/pyrrole scaffolds by a slight modification of starting materials. Moreover, the synthesized cyclopenta[]furans exhibit good fluorescence properties with quantum yields ranging from 0.

Phosphine-Catalyzed Nucleophilic Ring Opening of Cyclopropenones with Sulfoximines to Access -α,β-Unsaturated Acyl Sulfoximines.

Herein, we describe the formation of biologically relevant -α,β-unsaturated acyl sulfoximines via phosphine-catalyzed C-C bond activation of cyclopropenones with weakly nucleophilic sulfoximines. The new process does not require a transition metal or external oxidant and displays high regioselectivity and exclusive E-selectivity. Other salient features of the method are a broad substrate scope, high compatibility with various functional groups, and high atom economy.

Cardiovascular disease risk and Lung cancer screening for Early Assessment of Risk (project CLEAR) in Missouri: A protocol for a mixed methods study.

Background: Lung cancer and atherosclerotic cardiovascular disease (ASCVD) are leading causes of mortality in the United States, sharing common risk factors like smoking and age. Preventive care for these conditions is often siloed, leading to missed opportunities to prevent ASCVD-related mortality in lung cancer screening (LCS) patients. In various trial settings, patients undergoing LCS were more likely to die from ASCVD than from cancer; however, less than half of eligible patients got statin prescription.

Evaluating a community academic partnership to advance equity-focused cancer genetic implementation research: a qualitative analysis of partner perspectives.

Background: Forming community academic partnerships (CAPs) can increase the applicability, translation, and dissemination of implementation research focused on addressing health inequities within the community setting. We aimed to explore community and academic partners' perspectives on their participation in a novel, multi-disciplinary cancer genetic equity CAP focused on developing a multi-level intervention for breast, ovarian, prostate, and pancreas cancers.

Methods: We conducted semi-structured interviews with CAP members.