Potential missed opportunities to improve long-term liver allograft health.

Long-term patient and allograft health after liver transplantation remain suboptimal because of alloimmune complications, malignancy, and consequences of the metabolic syndrome, often exacerbated by current standard of care immunosuppression. There is emerging evidence that FDA-approved pharmacologic interventions and medications currently in clinical trials for other disease processes-including HMG-coA-reductase inhibitors, aspirin, obesity and metabolic dysfunction-associated steatohepatitis treatments and microbiome interventions reduce complications of chronic liver injury in general and may offer promising off label benefits to potentially enhance allograft and patient health post-liver transplant. These agents work through diverse mechanisms such as reducing inflammation, improving metabolic disorders, promoting immune tolerance, and preventing or even reversing fibrosis.

Mosaic Loss of Y Chromosome Defines a Proximal Tubular Cell State Associated with Recovery from DGF and of Allograft Quality and Functional Reserve Post DCD Kidney Transplantation.

Objective: To determine the drivers of proximal tubular cell regeneration and repair over time in the setting of recovery from delayed graft function (DGF) post donation after cardiac death (DCD) kidney transplantation.

Background: DCD Kidney allografts are at increased risk of graft loss. Despite this, due to organ shortages, DCD transplantation is increasing, which offers a novel and valuable platform for the study of adaptive/maladaptive repair mechanisms after injury.

Dialysis Preparedness and Access to the Transplant Waitlist: Evidence From a National United States Cohort Study.

Introduction: Individuals who initiate dialysis for kidney failure do so with different levels of preparedness. Whether this has downstream effects for access to kidney transplant is unknown.

Methods: We identified adults (aged ≥ 18 years) initiating dialysis between 2015 and 2019 from the United States Renal Data System and followed-up with them until waitlisting, death, or end of follow-up (December 31, 2021), whichever occurred first.

Outcomes of Photorefractive Keratectomy in First-Degree Relatives of Patients With Keratoconus.

Purpose: The aim of this study was to evaluate the safety and efficacy of photorefractive keratectomy (PRK) for treating myopic astigmatism in first-degree relatives of patients with keratoconus.

Methods: This retrospective comparative interventional case series included 146 eyes of 73 consecutive first-degree relatives of patients with keratoconus (group 1). A control group consisted of 150 right eyes from 150 consecutive individuals with no family history of keratoconus (group 2).

Practices in the management of kidney transplant candidates and recipients with obesity: A survey of United States transplant programs.

There is growing kidney transplant program-level interest in addressing obesity. The American Society of Transplantation Kidney Pancreas Community of Practice Obesity Work Group surveyed US programs to characterize evaluation, listing, and weight management practices. A web-based survey was administered to professionals involved in kidney transplant care (transplant nephrologists/surgeons/coordinators/dietitians, endocrinologists, bariatric surgeons, and obesity medicine specialists) from May 2024 to September 2024.