Additional Axillary Disease After Neoadjuvant Chemotherapy for Patients with Clinically Node-Negative but Sentinel Node-Positive Disease.

Background: Axillary lymph node dissection (ALND) is associated with considerable risk of arm morbidity. This study aimed to identify risk factors for additional disease found at ALND in patients with a diagnosis of clinically node-negative (cN0) breast cancer who had sentinel lymph node (SLN) metastasis after neoadjuvant chemotherapy (NACT) as a help to identify patients for whom ALND may be safely omitted.

Methods: This retrospective national cohort study analyzed Danish patients with a diagnosis of cT1-3 breast cancer and cN0 disease from October 2016 to November 2022 but a positive SLN biopsy after NACT.

The association between lymph node status and the tumor size in breast cancer - results from the Danish Breast Cancer Group (DBCG).

Background And Purpose: The association between the tumor size and the risk of lymph node metastasis (LNM) is well known. The purpose of this study is to describe a new model for predicting the occurrence of LNM at an earlier time for breast cancer patients where at a given time this association is known. Patient/material and methods: The subjects studied were 59,400 breast cancer patients treated in the period 1995-2012 and registered in the Danish Breast Cancer Group (DBCG) database.

Specification of self-reported late-term impairments 3-7 years after primary breast cancer treatment: a nationwide cross-sectional study among Danish breast cancer survivors.

Purpose: To describe the characteristics of Danish women treated for primary breast cancer, the prevalence and severity of self-reported late-term impairments, and the registration of these impairments in the Danish National Patient Registry.

Methods: This is a nationwide cross-sectional survey study. A nationwide sample of 9927 women were invited to complete a questionnaire on late-term impairments, including shoulder impairment, lymphedema, fatigue, and chemotherapy-induced neuropathy.

Effectiveness of an individualised treatment plan compared with a standard exercise programme in women with late-term shoulder impairments after primary breast cancer treatment: a randomised controlled trial.

Background And Purpose: Research focuses on lymphedema, yet up to 50% face chronic shoulder issues 6 years post-treatment, while rehabilitation for this group is unclear. This trial aimed to assess the clinical effects of a shoulder expert assessment followed by an individualised treatment plan (Intervention Group; IG) compared with standardised exercises delivered as a pamphlet (Control comparator Group; CG), on changes in Shoulder Pain and Disability Index (SPADI) from baseline to week 12.

Material And Methods: This 12-week, assessor-blinded, parallel-group randomised controlled trial included women with late-term shoulder impairments 3-7 years post-breast cancer.