Development and Validation of PARCOMS Composite Scales for Assessing Disease Progression and Treatment Effects in Parkinson's Disease.

Introduction: Measures designed to comprehensively assess Parkinson's disease (PD) irrespective of disease stage and treatment status may be unable to capture nuances in disease progression, particularly in early-stage PD. The objective of this paper is to develop PARkinson's COMposite Scales (PARCOMS) with increased responsiveness to clinical decline using items of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) for three discrete cohorts of patients.

Methods: Patients with confirmed PD from the Parkinson's Progression Markers Initiative (PPMI) data were assigned to three cohorts based on use of dopaminergic treatment, stage of disease, and presence of motor complication.

"Other" Substance Use Among American Indian Reservation-Area High School Youth.

Objective: High school youth have an elevated risk of substance use. Some substances (e.g.

A structural equation model test of affect, family warmth, and substance use among American Indian reservation-based adolescents.

Objective: This study examined moderating effects of family warmth on relationships between positive and negative affect and alcohol and cannabis use among American Indian (AI) youth.

Method: Participants were 5,831 AI students (seventh-12th grade) surveyed during the 2021 and 2022 school years. Students completed measures of positive and negative affect, family warmth, and past year alcohol and cannabis use.

Could life story work support relational autonomy in advance care planning? Stories from the EARLI project.

Objectives: Advance care planning has evolved from a narrow focus on advance directives completion towards a greater emphasis on ongoing conversations and value clarification. This evolution aligns with a relational perspective on autonomy in a social context. However, limited research explores how relational autonomy might be operationalised in practice.

The Effects of Palmar Cooling on Repeated Sprinting Ability: A Randomized Controlled Clinical Trial.

Evidence supports the role of palmar cooling to improve exercise performance, especially with endurance and resistance activities. The aim of this randomized placebo-controlled trial was to explore the effects of palmar cooling on repeated sprinting performance and recovery. Fifteen graduate students were randomly assigned to either a palmar cooling intervention or placebo group (males: n = 8, females: n = 7; Avg.