Real-time monitoring of selective laser sintering 3D printing process for lamivudine content quantification in the printlets: a modern solution to a modern problem.

Quality control of drug products is an essential step in pharmaceutical manufacturing. It is often time-consuming and requires expensive equipment. Process analytical technology tools are typically integrated into the manufacturing process to monitor quality, thereby reducing time and costs.

Computational identification of membrane proteins for vaccine design against drug-resistant Moraxella catarrhalis.

Moraxella catarrhalis is a Gram-negative diplococcus bacterium and a common respiratory pathogen, implicated in 15-20% of otitis media (OM) cases in children and chronic obstructive pulmonary disease (COPD) in adults. The rise of drug-resistant Moraxella catarrhalis has highlighted the urgent need for the potent vaccine strategies to reduce its clinical burden. Despite a mortality rate of 13%, there is no FDA-approved vaccine for this pathogen.

Leveraging topological reactivity of cellulose nanocrystals with allomorph II (CNC-II) to create temperature-sensitive systems for ibuprofen delivery.

Cellulose nanocrystals (CNCs) have garnered attention for their renewable and reactive nature, yet CNC allomorph II (CNC-II) remains underexplored compared to the extensively studied CNC-I. This study bridges this gap by introducing a two-step carboxylamine condensation strategy to conjugate poly(ethylene glycol) (PEG) onto CNC-II via ethylenediamine, leveraging the high topochemical reactivity of CNC-II. Utilizing bicarboxylate-capped PEG as a probe, quartz crystal microbalance with energy dissipation (QCM-D) assays revealed a significant reactivity increase of 16.

Decoding Leishmania in Equines: A Comparative Analysis of Molecular Targets.

Parasitic diseases caused by Leishmania spp. create considerable health concerns in animals, resulting in a considerable financial impact. They causes a complex infection in equines, affecting weight gain, skin, liver, and spleen.

The Triadic Relationship Between Nonalcoholic fatty liver disease, Type 2 Diabetes, and cardiovascular disease: From Molecular Mechanisms to Clinical Management.

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) represent interconnected metabolic disorders with multifaceted etiology, demonstrating bidirectional relationships and pronounced associations with cardiovascular diseases (CVDs). Despite extensive research, significant knowledge gaps persist regarding the temporal progression of these comorbidities, optimal screening strategies for high-risk populations, and personalized therapeutic approaches targeting the hepatic-cardiac-metabolic axis simultaneously. Current literature lacks a comprehensive analysis of phenotypic heterogeneity within NAFLD-T2DM-CVD clusters and fails to address sex-specific and ethnic variations in disease progression patterns adequately.