Chronic illnesses requiring home-based palliative care and their impact on families in an urban resettlement colony of Delhi, India.

Background: Non-communicable diseases are a growing public health concern in India. However, limited knowledge of community-based need for palliative care has contributed to its poor access.

Objective: To assess the community-based palliative care needs, social security access, and the economic burden on families requiring home-based palliative care.

Assessment of Ecological and Human Health Risk Associated with Toxic Metals from the Consumption of Vegetables Exposed to Low Quality Irrigation Water of Industrial Zones in Semi-arid Regions.

The aim of the study was to evaluate the toxic metals (TMs) pollution, bioaccumulation and its potential health risk via consumption of different vegetables irrigated by different water sources released from industrial estates of Khyber Pakhtunkhwa. Water (fresh and waste), soil and vegetables samples were collected in triplicates and acid digested. Digestion of samples were followed by evaporation and filtration and then assessed for TMs via atomic absorption spectrophotometer.

Large-Scale Dermatopathology Dataset for Lesion Segmentation: Model Development and Analysis.

Background: With the increasing incidence of skin cancer, the workload for pathologists has surged. The diagnosis of skin samples, especially for complex lesions such as malignant melanomas and melanocytic lesions, has shown higher diagnostic variability compared to other organ samples. Consequently, artificial intelligence (AI)-based diagnostic assistance programs are increasingly needed to support dermatopathologists in achieving more consistent diagnoses.

Lipid-based nanoparticles: advancing therapeutic strategies for vitiligo management.

Vitiligo, a chronic autoimmune disorder characterized by the presence of depigmented skin patches, remains a therapeutic challenge due to its multifactorial pathogenesis and the absence of highly effective treatment options. Although the exact etiology of vitiligo is not fully understood, factors such as genetic factors, oxidative stress, autoimmunity, and inflammation are implicated in the destruction of melanocytes. Current therapeutic strategies primarily focus on modulating immune responses and alleviating oxidative stress.

Bacteria-Mitochondria Cross-talk: How Microbes Regulate Mitochondrial Dynamics and Bioenergetics of Host Cells.

Mitochondria are the cellular powerhouses and are considered to be central to energy metabolism, dynamics, and homeostasis. There is growing evidence that the gut microbiome regulates mitochondrial biogenesis, dynamics (fission, fusion, mitoph-agy), and bioenergetics, and that it does so by connecting bacterial metabolites and signaling molecules. This review discusses the molecular mechanisms that underlie the interplay between bacteria and mitochondria, with a particular focus on the modulation of mitochondrial activities by microbial products, including bile acids, immunological mediators, and short-chain fatty acids (SCFAs).