Gromwell () ameliorates age-related loss of skeletal muscle mass and function in mice.

Sarcopenia, an age-related disease characterized by the loss of skeletal muscle mass and function, is a growing concern in the aging population. This study investigated the potential of Gromwell (Lithospermum erythrorhizon, LE) to ameliorate sarcopenia in aged mice and the effect of lithospermic acid (LA), a bioactive compound found in LE, on cellular senescence in aged human skeletal muscle myoblast (HSMM) cells. Nineteen-month-old male C57BL/6 mice were fed a diet supplemented with 0.