Publications by authors named "Lyle Suh"
Moyamoya is characterized as a non-atherosclerotic and non-inflammatory vasculopathy that leads to progressive stenosis of the intracranial internal carotid arteries as well as the Circle of Willis. While it can be idiopathic (Moyamoya disease) or associated with another condition (Moyamoya syndrome), there is a characteristic 'puff of smoke' sign that can be appreciated on cerebral angiography.
View Article and Find Full Text PDFPositioning SUMO as an immunological facilitator of oncolytic viruses for high-grade glioma.
Front Cell Dev Biol
October 2023
Article Synopsis
- Oncolytic viral (OV) therapies are a new treatment option for hard-to-treat cancers like glioblastoma in the central nervous system but face challenges in effectiveness due to delivery issues and immune responses.
- The SUMO pathway, which regulates various physiological processes, plays a role in both CNS cancers and viral interactions, making it a target for enhancing OV treatments.
- The authors provide an overview of the SUMO pathway's impact on CNS malignancies, the current status of OV therapies, and how the SUMO pathway interacts with the viral lifecycle and immune responses.
Objective: The prognostic impact of intra-operative tumor spillage (ITS) during minimally invasive surgery (MIS) for endometrial cancer (EC) is not well studied. The objective of this study was to determine if there is an association between ITS and EC recurrence.
Methods: We performed a case-control study of patients with a laparoscopic or robot-assisted hysterectomy with EC on final pathology between 2017 and 2022 and compared those with (case) and without (control) a subsequent EC recurrence.