Long-term Outcomes And Survival Predictors In Patients With Ectopic ACTH Syndrome: Data From A Retrospective Cohort Study.

Background: Ectopic ACTH syndrome (EAS) is caused by non-pituitary neuroendocrine tumor (NET) which produces adrenocorticotropic hormone (ACTH).

Objective: To identify survival predictors and to analyze long-term outcomes in patients with EAS.

Methods: Medical records of patients with verified EAS between 1990 and 2024 were analyzed to obtain the initial clinical and biochemical data along with subsequent interventions and survival outcomes.

Study of Adhesion-Cohesive Interactions of Modified Bitumen Compositions.

The aim of the work was to study the effect of additive concentration on changes in the adhesive and cohesive strength of bitumen. To evaluate the effectiveness of modifiers in the composition of binary and triple bitumen systems in relation to mineral fillers of two grades, the method of determination of the adhesive efficiency and thermodynamic calculations of adhesion and cohesion work were used. The following compounds were used as additives: synthesized from the oil refining waste and (waste sealing liquid).

Secondary structure analysis of proteins within the same topology group.

The native conformation of a protein plays a decisive role in ensuring its functionality. It is established that the spatial structure of proteins may exhibit a greater degree of conservation than the corresponding amino acid sequences. This study aims to clarify structural distinctions between homologous and non-homologous proteins with identical topology.

The Effect of the Microstructure and Viscosity of Modified Bitumen on the Strength of Asphalt Concrete.

The purpose of these studies was to establish the influence of the microstructural and rheological characteristics of modified bitumen compositions on the strength indicators of asphalt concrete. The effect of additives concentration on the rheological characteristics and microstructure of binary "bitumen-surfactant", "bitumen-AG-4I", and ternary "bitumen-AG-4I-AG-4I" systems has been studied. To assess the effect of bitumen dispersion on the physical and mechanical characteristics of modified asphalt concrete samples, the compressive strength value was determined.

Increasing the Adhesion of Bitumen to the Surface of Mineral Fillers through Modification with a Recycled Polymer and Surfactant Obtained from Oil Refining Waste.

The purpose of this study was to optimize the processes of wetting fillers by varying the content of such additives as a surfactant and polymer in bitumen-mineral compositions in order to achieve optimal performance. The cosine of the contact angle was used as a criterion for assessing the adhesion of the bitumen binder to the surface of crushed stone. The effect of the additives' concentration on surface tension and adhesive efficiency in binary and ternary bitumen compositions was studied.

[Moscow scientific schools on the field of internal medicine in the second half of the XIX - early XX centuries: comparative characteristics].

Peculiarities and comparative characteristics of three main Moscow schools on the field of internal medicine of the second half of the XIX - early XX centuries are discussed: schools of Grigory Zakharyin, Alexey Ostroumov and Vassily Shervinsky - Leonid Golubinin; the legitimacy to acknowledge scientific clinical schools of Mikhail Cherinov and Nikolay Golubov is disputed. The arguments are provided that of the Moscow therapeutic schools, it was the Shervinsky-Golubinin school, and not the Zakharyin or Ostroumov school, that played the most significant role in the formation of the internal medicine in the USSR, in passing the accumulated knowledge and ideas to therapeutic elites in the USSR.

[Ankle distraction hinged motion arthroplasty in the Ilizarov frame].

Objective: To study distraction hinged motion arthroplasty of the ankle joint in combined treatment of osteoarthritis in terminal stages.

Material And Methods: Ankle distraction hinged motion arthroplasty in the Ilizarov frame was performed in 10 patients with terminal post-traumatic osteoarthritis (mean age 54±6.2 years).

[Short-term and long-term remission after endoscopic transnasal adenomectomy in patients with acromegaly].

Background: Neurosurgery is the most effective treatment for acromegaly. As most of the patients present with macroadenomas, surgical treatment is not always successful, even with the expert level of a neurosurgeon. Assessment of the postoperative remission rates in acromegaly preoperative predictors of treatment efficacy is an urgent task of modern research.

ANKLE DISTRACTION ARTHROPLASTY: A SYSTEMATIC REVIEW.

Epidemiological data suggest 9-15% of ankle joint osteoarthritis (AOA) in the general population. One of the methods of delaying radical intervention is ankle joint distraction arthroplasty of the ankle joint (ADA), including a combination of various techniques. The lack of publications summarizing the maximum possible clinical data on ADA for more than 50 years of the method's history justifies the need for a review.

Molecular Dynamics Simulation Study of the Self-Assembly of Phenylalanine Peptide Nanotubes.

In this paper, we propose and use a new approach for a relatively simple technique for conducting MD simulation (MDS) of various molecular nanostructures, determining the trajectory of the MD run and forming the final structure using external force actions. A molecular dynamics manipulator (MD manipulator) is a controlled MDS type. As an example, the applicability of the developed algorithm for assembling peptide nanotubes (PNT) from linear phenylalanine (F or Phe) chains of different chirality is presented.

Exploration of the Adsorption Reduction of the Pigment Aggregates Strength under the Effect of Surfactants in Water-Dispersion Paints.

This article presents the results of studying the disaggregation of titanium dioxide in water-dispersion compositions based on an acrylic film-forming agent under the action of a surfactant. The possibility of using polyether siloxane copolymer (PC) and sodium polyacrylate (NaPA) in paint and varnish compositions as modifying additives of the dispersing effect is proved. The correlation between the dispersing effect of surfactants and the amount of their adsorption on the pigment is proved.

[Differences in plasma miRNA levels in inferior petrosal sinus samples of patients with ACTH-dependent Cushing's syndrome].

Background: For the last decades microRNAs (miR) have proven themselves as novel biomarkers for various types of diseases. Identification of specific circulating microRNA panel that differ patient with Cushing's disease (CD) and ectopic ACTH syndrome (EAS) could improve the diagnostic procedure.

Aim: to evaluate the differences in miR levels in plasma samples drained from inferior petrosal sinuses in patients with CD and EAS.

Quantitative Assessment of Chirality of Protein Secondary Structures and Phenylalanine Peptide Nanotubes.

In this study we consider the features of spatial-structure formation in proteins and their application in bioengineering. Methods for the quantitative assessment of the chirality of regular helical and irregular structures of proteins are presented. The features of self-assembly of phenylalanine (F) into peptide nanotubes (PNT), which form helices of different chirality, are also analyzed.

Modeling of Self-Assembled Peptide Nanotubes and Determination of Their Chirality Sign Based on Dipole Moment Calculations.

The chirality quantification is of great importance in structural biology, where the differences in proteins twisting can provide essentially different physiological effects. However, this aspect of the chirality is still poorly studied for helix-like supramolecular structures. In this work, a method for chirality quantification based on the calculation of scalar triple products of dipole moments is suggested.

Circulating Plasma MicroRNA in Patients With Active Acromegaly.

Context: Excessive production of growth hormone causes marked multiorgan changes in patients with acromegaly, which may involve epigenetic mechanisms.

Objective: To evaluate differences in circulating microRNAs (miRNAs) associated with chronic growth hormone overproduction in adults.

Design And Setting: A cross-sectional case-control study was conducted at a tertiary medical center.

[Current aspects of diagnosis and treatment of adult GH-deficiency].

Adult growth hormone (GH) deficiency (AGHD) is a condition characterized by alterations in body composition, lipid and carbohydrate metabolism, bone mineral density and poor quality of life; however, clinical presentations of AGHD are mostly non-specific. Untreated AGHD is associated with increased cardiovascular morbidity and mortality. Stimulation tests are used for the diagnosis: insulin tolerance test, glucagon stimulation test, growth-hormone releasing hormone and arginine stimulation test.

[Expression of plasma microRNA in patients with acromegaly].

Background: microRNA is a class of small non-coding RNA molecules involved in posttranscriptional regulation of gene expression. MicroRNAs are detectable in blood in stable concentrations, which makes them promising biomarkers for various diseases.

Aim: to assess plasma microRNA expression in patients with active acromegaly compared with healthy controls.

Coping Strategies and Personality Profile Characteristics of People Whose Parents Were Alcohol Addicts.

The relevance of this research is due to the wide prevalence of addictive behavior and the insufficient knowledge of the coping strategies of patients and their families. The purpose of this research was to investigate the resource factors and coping strategies of adults with alcohol-addicted parents and to make recommendations for psychological counseling for these people. The sample consisted of 52 subjects-who were participants in a twelve-step rehabilitation program for adult people whose parents had alcohol addictions-and 50 controls.

Strong long-range electron-phonon interaction as possible driving force for charge ordering in cuprates.

A model resulting in charge ordering (CO) similar to that observed in cuprate superconductors is under study. It includes strong long-range electron-phonon interaction (EPI) and high density of correlated carriers. Coexistence of large bipolarons and delocalized carriers is a feature of such system.

Effects of active acromegaly on bone mRNA and microRNA expression patterns.

Objective: To evaluate the response of bone to chronic long-term growth hormone (GH) and insulin-like growth factor-1 (IGF1) excess by measuring the expression of selected mRNA and microRNA (miR) in bone tissue samples of patients with active acromegaly.

Design: Case-control study.

Methods: Bone tissue samples were obtained during transsphenoidal adenomectomy from the sphenoid bone (sella turcica) from 14 patients with clinically and biochemically confirmed acromegaly and 10 patients with clinically non-functioning pituitary adenoma (NFPA) matched by sex and age.

Contrast degradation in a chirped-pulse amplifier due to generation of prepulses by postpulses.

Experiment and modeling show that the refractive index nonlinearity can significantly degrade the contrast of a chirped-pulse amplifier seeded with a pulse and a single postpulse. Multiple powerful non-equidistant pre- and postpulses are generated. For a Gaussian pulse and a hat-top beam, an incident postpulse of energy W results in a prepulse of energy 0.

Ultrabroad-bandwidth multifrequency Raman generation.

We report on the modeling of transient stimulated rotational Raman scattering in H(2) gas. We predict a multifrequency output, spanning a bandwidth greater than the pump frequency, that may be generated without any significant delay with respect to the pump pulses. The roles of dispersion and transiency are quantified.