Publications by authors named "Luoting Chen"
Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress.
Front Pharmacol
August 2025
Background: Hepatic fibrosis emerges as a pathological hallmark in the pathogenesis of chronic hepatopathies. is a traditional Chinese herb used to treat liver disease. However, the anti-hepatic fibrosis effect of fangchinoline (FAN), an active ingredient of , has not been reported.
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- Dysregulation of redox homeostasis and oxidative stress are linked to the development of hepatocellular carcinoma (HCC), with Fangchinoline (FAN) being a potential anti-cancer drug not yet fully studied for its effects on oxidative stress.
- The research aims to investigate how FAN can prevent HCC by regulating oxidative stress and to uncover the molecular mechanisms involved, using both animal models and cell lines.
- Findings indicate that FAN inhibits cell proliferation and tumor formation in HCC by promoting ROS accumulation, activating the Nrf2 pathway, and engaging TRIM7, which helps stabilize Nrf2 through a feedback loop.
Understanding the dynamic evolution of hemicellulose during Pinus taeda L. growth.
Int J Biol Macromol
July 2024
Pinus taeda L. is a fast-growing softwood with significant commercial value. Understanding structural changes in hemicellulose during growth is essential to understanding the biosynthesis processes occurring in the cell walls of this tree.
View Article and Find Full Text PDFAttenuation of Perfluorooctane Sulfonate-Induced Steatohepatitis by Grape Seed Proanthocyanidin Extract in Mice.
Biomed Res Int
September 2021
Perfluorooctane sulfonate (PFOS), an environmentally persistent pollutant, has been revealed to elicit hepatic toxicity. In the current study, we investigated the protective role of grape seed proanthocyanidin extract (GSPE) against PFOS-caused steatohepatitis in mice. Animals were exposed intragastrically to PFOS (10 mg/kg/day), GSPE (150 mg/kg/day), or their combination.
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