Diagnostic and prognostic multimodal prediction models in Alzheimer's disease: A scoping review.

BackgroundMultimodal prediction models for Alzheimer's disease (AD) are emerging as promising tools for improving detection and informing prognosis.ObjectiveTo summarize the predictive objectives, constituting predictors and algorithms, and performance of existing multimodal prediction models.MethodsWe performed a systematic literature search in Medline, Embase, and Web of Science up to January 15, 2024, to identify prediction models covering the full spectrum of AD, from the preclinical stage to subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD dementia.

Social relationship factors, depressive symptoms, and incident dementia: a prospective cohort study into their interrelatedness.

Background: Different aspects of social relationships (e.g., social network size or loneliness) have been associated with dementia risk, while their overlap and potentially underlying pathways remain largely unexplored.

Facing the Next "Geriatric Giant"-A Systematic Literature Review and Meta-Analysis of Interventions Tackling Loneliness and Social Isolation Among Older Adults.

Objectives: Loneliness and social isolation are associated with adverse health outcomes, especially within the older adult population, underlining the need for effective interventions. This systematic review and meta-analysis aims to summarize all available evidence regarding the effectiveness of interventions for loneliness and social isolation, to map out their working mechanisms, and to give implications for policy and practice.

Design: Systematic literature review and meta-analysis.

Associations between social health factors, cognitive activity and neurostructural markers for brain health - A systematic literature review and meta-analysis.

Social health factors (e.g., social activities or social support) and cognitive activity engagement have been associated with dementia risk, but their neural substrates have not been well established.