Publications by authors named "Luciana LeSueur-Maluf"
Alcoholic neuropathy associated with chronic alcohol intake.
Maria Eduarda Tessitore
,
Laís da Silva Pereira-Rufino
,
Carlos Eduardo Panfilio
,
Rita de Cassia Sinigaglia
,
Odair Aguiar Júnior
IBRO Neurosci Rep
December 2022
Article Synopsis
- Alcoholic neuropathy (AN) affects chronic alcohol drinkers, damaging the peripheral nervous system and leading to issues with sensory, autonomic, and motor functions.
- The study involved male Wistar rats divided into a Control group and an Alcohol group, which consumed an alcohol solution for eight weeks, followed by various sensorimotor tests and analysis of their sciatic nerve.
- Results revealed that chronic alcohol intake caused demyelination and heightened sensitivity, showing a strong relationship between blood alcohol levels and nerve damage, alongside behavioral changes like hyperactivity and altered gait.
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Further to the symptoms resulting from demyelination, new studies point to the involvement of neuroinflammation and white matter abnormalities in psychiatric disorders and neurodegenerative diseases. Cuprizone, a model of MS, produces consistent demyelination and elicits behavioural, morphological and inflammatory changes in animals that share some similarities with those observed in humans.
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