Impaired glymphatic system function in relapsing-remitting multiple Sclerosis: Insights from diffusion tensor imaging along the perivascular space (DTI-ALPS).

In relapsing-remitting multiple sclerosis (RRMS) patients, an enlarged perivascular space, cognitive impairment, and inflammatory immune response has been associated with the glymphatic dysfunction. Therefore, we employed the diffusion tensor image analysis along the perivascular space (DTI-ALPS) to evaluate glymphatic function in RRMS patients. The study included 39 RRMS patients and 34 age- and gender-matched healthy controls (HC).

Reinforcement learning-based pinning control for synchronization suppression in complex networks.

Synchronization in complex networks is a ubiquitous and important phenomenon with implications in various fields. Excessive synchronization may lead to undesired consequences, making desynchronization techniques essential. Exploiting the Proximal Policy Optimization algorithm, this work studies reinforcement learning-based pinning control strategies for synchronization suppression in global coupling networks and two types of irregular coupling networks: the Watts-Strogatz small-world networks and the Barabási-Albert scale-free networks.

Glyceryl triacetate promotes blood-brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice.

Background: Lipid metabolism has a crucial role in neural repair in neurodegenerative diseases. We recently revealed that lipogenesis-mediated interleukin-33 (IL-33) upregulation lead to blood-brain barrier (BBB) repair after ischemic stroke. However, manipulating the key enzyme fatty acid synthase (FASN) to enhance lipogenesis was very challenging.

Conditional cross-map-based technique: From pairwise dynamical causality to causal network reconstruction.

Causality detection methods based on mutual cross mapping have been fruitfully developed and applied to data originating from nonlinear dynamical systems, where the causes and effects are non-separable. However, these pairwise methods still have shortcomings in discriminating typical network structures, including common drivers, indirect dependencies, and facing the curse of dimensionality, when they are stepping to causal network reconstruction. A few endeavors have been devoted to conquer these shortcomings.

Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.

Anesthetics such as sevoflurane are commonly administered to infants and children. However, the possible neurotoxicity caused by prolonged or repetitive exposure to it should be a concern. The neuroprotective effects of metformin are observed in many models of neurological disorders.

Lactate modulates microglial inflammatory responses after oxygen-glucose deprivation through HIF-1α-mediated inhibition of NF-κB.

Metabolic adaption drives microglial inflammatory responses, and lactate shapes immunological and inflammatory states. However, whether lactate was involved in the regulation of microglial inflammatory responses after cerebral ischemia remains unclear. In this study, the expression of iNOS, arginase-1, phosphorylated NF-κB p65 and IκB-α, and HIF-1α in BV2 cells after oxygen-glucose deprivation (OGD) were detected by western blotting and immunofluorescence.