Publications by authors named "Lisa Kleid"
Article Synopsis
- HLA mismatches between lung transplant donors and recipients can lead to the formation of donor-specific antibodies, particularly HLA-DQ-dnDSA, which can negatively affect transplant outcomes.
- The study analyzed data from 183 lung transplant patients from 2012 to 2020, finding that 22.9% developed HLA-DQ-dnDSA, with homozygous HLA-DQ patients at a higher risk compared to heterozygous patients.
- The research identified specific HLA-DQ combinations and eplets that increase the risk for dnDSA development, suggesting that improving immunological compatibility could enhance graft outcomes.
Molecular matching is a new approach for virtual histocompatibility testing in organ transplantation. The aim of our study was to analyze whether the risk for de novo donor-specific HLA antibodies (dnDSA) after lung transplantation (LTX) can be predicted by molecular matching algorithms (MMA) and their combination. In this retrospective study we included 183 patients undergoing LTX at our center from 2012-2020.
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