Publications by authors named "Lincy Varghese"

Biopolymer-derived polyelectrolyte complexes (PECs) are a class of materials that have emerged as promising candidates for developing advanced electrochemical sensors due to their tunable properties, biocompatibility, cost-effective production, and high surface area. PECs are formed by combining positively and negatively charged polymers, resulting in a network with intriguing properties that can be tailored for specific sensing applications. The resultant PECs-based nanocomposites were used to modify the glassy carbon electrode (GCE) to detect the sulfamethazine (SFZ) antibiotic drug.

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The accelerated development of special-wetting polymeric materials with hierarchical pores for membrane applications is crucial to effectively separating water-soluble and insoluble pollutants, such as oily wastewater, emulsion, organic pollutants, and heavy metals. This pressing environmental and socioeconomic issue requires the implementation of effective remediation technologies. In this study, we successfully fabricated an environmentally friendly membrane with a flexible property by combining biopolymers and magnetic nanohybrids of iron oxide (FeO)-doped tungsten oxide (WO) through a thermal-induced phase separation process (TIPS).

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In recent years, the usage of nitroaniline has played a vital role in pharmaceutical formulations as it is a crucial ingredient in the synthesis of pesticides and dyes. However, the level of nitroaniline existing in industrial waste keeps rising the environmental contamination. Thus, monitoring of active nitro-residuals becomes more significant in reducing the toxicity of the ecosystem.

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Molybdenum disulfide (MoS) surface functionalization was performed with a catechol-containing polymer sodium alginate (SA) and dopamine (DA) through simultaneous MoS exfoliation and self-polymerization of DA. The MoS/SA-PDA nanocomposite was characterized using spectroscopic, microscopic, and electroanalytical techniques to evaluate its electrocatalytic performance. The electrocatalytic behavior of the MoS/SA-PDA nanocomposite modified electrode for the detection of acebutolol (ACE), a cardio-selective β-blocker drug was explored  through cyclic voltammetric and differential pulse voltammetric techniques.

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Synaptotagmin 7 (Syt7) is expressed in cardiac sympathetic nerve terminals where norepinephrine (NE) is released in both Ca(2+)-dependent exocytosis and Ca(2+)-independent norepinephrine transporter (NET)-mediated overflow. The role of Syt7 in the regulation of NE release from cardiac sympathetic nerve terminals is tested by employing a Syt7 knock-in mouse line that expresses a non-functional mutant form of Syt7. In cardiac sympathetic nerve terminals prepared from these Syt7 knock-in mice, the Ca(2+)-dependent component of NE release was diminished.

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