Comparative analysis of Attention Deficit Hyperactivity Disorder in China and worldwide based on the Global Burden of Disease study.

Background: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by difficulties in maintaining attention, excessive activity, impulsive behavior, and challenges in organizing and executing tasks. These symptoms can pose challenges in various settings, including home, school, and work, imposing a significant burden not only on affected individuals and their families but also on the global healthcare system.

Method: This study utilized open data from the Global Burden of Disease database covering the years 1990-2021 to analyze the characteristics of the burden of ADHD in China and worldwide, including incidence, prevalence, and adjusted lifespan for disability (DALYs).

Cryopreservation of sturgeon egg mitochondria and their replacement in germline: A novel strategy for maternal genetic preservation in sturgeons.

Nearly all sturgeon species are critically endangered, necessitating the development of innovative approaches to preserve their genetic diversity and support population recovery. Unlike sperm, the cryopreservation of fish eggs or embryos remains technically unscalable because of the inherent structural and compositional barriers. Mitochondria are abundant in germ plasm and indispensable in the formation of primordial germ cells (PGCs).

Mitochondria as indispensable yet replaceable components of germ plasm: insights into PGCs specification in sturgeons.

In Brief: The mitochondria within germ plasm contribute to the formation and specification of primordial germ cells (PGCs) in non-teleost fishes regardless of their origin from germ plasm. This study offers new insights into germ cell biology and potential strategies for conserving matrilineal genetics in sturgeons.

Abstract: While it is widely recognised that mitochondria are components of germ plasm, their specific role in the formation and specification of PGCs remains poorly understood.

Machine learning predictive models for grading bronchopulmonary dysplasia: umbilical cord blood IL-6 as a biomarker.

Objectives: This study aimed to analyze the predictive value of umbilical cord blood Interleukin-6 (UCB IL-6) for the severity-graded BPD and to establish machine learning (ML) predictive models in a Chinese population based on the 2019 NRN evidence-based guidelines.

Methods: In this retrospective analysis, we included infants born with gestational age <32 weeks, who underwent UCB IL-6 testing within 24 h of admission to our NICU between 2020 and 2022. We collected their medical information encompassing the maternal, perinatal, and early neonatal phases.

Association between tumor necrosis factor α and uterine fibroids: A protocol of systematic review.

Background: This study will explore the association between tumor necrosis factor α (TNF-α) and uterine fibroids (UFs).

Methods: We will retrieve electronic databases in Cochrane Library, PUBMED, EMBASE, Web of Science, WANGFANG, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from inception to the present. All potential case-controlled studies investigating the association between TNF-α and UFs will be included in this study.