Publications by authors named "Lilli A Pazurek"
Article Synopsis
- Mitochondrial fusion and fission are vital for stress responses and managing metabolic changes, which involves the protein Opa1 in its various forms.
- The study involved creating mouse models with specific Opa1 isoforms to determine their role, showing that both cleavable and non-cleavable forms support embryo and adult mouse health.
- Opa1 processing isn't essential for dealing with metabolic or thermal stress but is crucial for longevity and heart health in mice with faulty energy production, indicating its importance in regulating heart growth and metabolism.
Lipid flippases of the P4-ATPase family are ATP-driven transporters that translocate lipids from the exoplasmic to the cytosolic leaflet of biological membranes. In the encapsulated fungal pathogen , the P4-ATPase Apt1p is an important regulator of polysaccharide secretion and pathogenesis, but its biochemical characterization is lacking. Phylogenetic analysis revealed that Apt1p belongs to the subclade of P4A-ATPases characterized by the common requirement for a β-subunit.
View Article and Find Full Text PDFLiquid-liquid phase separation (LLPS) has emerged as a key mechanism for intracellular organization, and many recent studies have provided important insights into the role of LLPS in cell biology. There is also evidence that LLPS is associated with a variety of medical conditions, including neurodegenerative disorders. Pathological aggregation of α-synuclein, which is causally linked to Parkinson's disease, can proceed via droplet condensation, which then gradually transitions to the amyloid state.
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