Impact of topical insulin as a therapeutic intervention for corneal wounds: A comprehensive systematic review and meta-analysis.

BackgroundPersistent epithelial defects (PEDs) are challenging corneal conditions with prolonged non-healing. Commonly associated with dry eye disease and neurotrophic keratopathy, PEDs can lead to severe complications. Topical insulin has emerged as a therapeutic option, promoting epithelial healing.

Adjuvant Use of Topical 0.05% Cyclosporine A in Primary Pterygium Recurrence Rate: A Systematic Review and Meta-analysis.

Purpose: To assess pterygium recurrence rates across various surgical techniques utilizing topical 0.05% cyclosporine A (CsA) as an adjuvant therapy versus surgical techniques alone in a meta-analysis.

Methods: We searched PubMed, Cochrane Database, Embase, and Web of Science for trials that compared pterygium recurrence rates between excision surgery with adjuvant 0.

Comprehensive assessment of the feasibility, safety, and efficacy of the pressure cooker technique in the treatment of brain arteriovenous malformations: Systematic review and meta-analysis.

Purpose: The Pressure Cooker Technique (PCT) is an endovascular technique for brain arteriovenous malformations (bAVMs) that can minimize reflux and inadvertent embolization compared with conventional techniques, leading to a safer and more controlled embolization. This systematic review and meta-analysis aimed to assess the feasibility, safety, and efficacy of PCT for bAVMs.

Methods: We searched PubMed, Embase, and Web of Science databases.

Treatment and outcomes of concomitant parasellar meningiomas and anterior circulation aneurysms: a systematic review and perspective in the endovascular era.

The coexistence of parasellar meningiomas and anterior circulation aneurysms is rare, and their anatomical proximity complicates diagnosis and treatment, making management challenging and risky. This study aims to assess the literature on the treatment strategies, clinical-surgical outcomes, and complications in such complex cases. We searched Pubmed, Embase, Scopus, and Web of Science databases following PRISMA guidelines for studies reporting clinical and/or surgical outcomes related to concomitant parasellar meningiomas and anterior circulation aneurysms.

Efficacy and Safety of Cannabinoids for Autism Spectrum Disorder: An Updated Systematic Review.

Autism Spectrum Disorder (ASD) lacks an established pharmacological treatment protocol, prompting interest in alternative therapeutic approaches, such as cannabidiol (CBD). This systematic review evaluates the potential efficacy and safety of CBD-rich formulations in managing ASD symptoms. A comprehensive search of PubMed, Embase, Scopus, Web of Science, and the Cochrane Library identified seven studies encompassing 494 patients from Brazil and Israel.

Cesium 131 seeds for high-grade gliomas: a systematic review and meta-analysis of gammatile as a brachytherapy innovation.

High-grade gliomas (HGG) are a neuro-oncology challenge due to their aggressive nature,with conventional therapies like radiation and chemotherapy often yielding limited success. Cesium-131 (Cs-131) brachytherapy is a promising adjunct due to its short half-life (9.7 days) and high energy, enabling targeted radiation delivery with less exposure.

Safety and Efficacy of 0.1% Cyclosporine Solutions in Dry Eye Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Cyclosporine A (CsA) is a primary treatment for dry eye disease (DED). Ophthalmic solutions containing CsA are available in concentrations of 0.05%, 0.

GLP-1 Receptor Agonists Use and Incidence of Glaucoma: A Systematic Review and Meta-Analysis.

Purpose: In patients with diabetes, glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) may protect against microvascular alterations and oxidative stress, both of which have been implicated in glaucoma. Multiple studies suggest a possible relation between GLP-1 RA use and the development of glaucoma. This study is a systematic review of the published literature regarding the incidence of glaucoma development in patients with type 2 diabetes treated with GLP-1 RAs compared with a control group.

Cataract in HIV Patients: A Systematic Review and Meta-Analysis.

HIV-induced AIDS attacks the immune system, leading to opportunistic infections. This syndrome has been linked to an increased risk of developing uveitis and subsequent cataracts. Consequently, cataract surgery may be associated with intra- and postoperative complications in HIV/AIDS patients.

Comparative efficacy and safety of sodium fluorescein-guided surgery versus standard white light for resection of brain metastases: a systematic review and meta-analysis.

Purpose: Recent studies have investigated if the sodium fluorescein-guided (SFg) improves the extent of resection of BMs when compared to standard white light (sWL). Therefore, we aimed to assess the comparative efficacy and safety of SFg and sWL for resection of BMs.

Methods: We searched Medline, Embase, and Cochrane Library databases following Cochrane and PRISMA guidelines for studies reporting comparative data of SFg and WL resection of BMs.