Publications by authors named "Libeth Rosas"
Clinical Trial Design Considerations for Hospitalised Patients With Ulcerative Colitis Flares and Application to Study Hyperbaric Oxygen Therapy in the NIDDK HBOT-UC Consortium.
Aliment Pharmacol Ther
December 2024
Article Synopsis
- Patients with ulcerative colitis (UC) experiencing severe flares in the hospital are a unique and high-risk group requiring specialized clinical trial designs.
- A multi-centre consortium is developing a trial for hyperbaric oxygen therapy, addressing important factors like inclusion/exclusion criteria, disease activity measures, and tailored care pathways.
- The study highlights the need for comprehensive outcome measures and standardized care practices while emphasizing the significance of early intervention and statistical planning in these small clinical trials.
Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones.
Int J Hyg Environ Health
June 2024
Background/aims: Pregnant women are exposed to persistent environmental contaminants, including per- and polyfluoroalkyl substances (PFAS) that disrupt thyroid function. However, it is unclear if PFAS alter maternal sex-steroid hormone levels, which support pregnancy health and fetal development.
Methods: In Illinois women with relatively high socioeconomic status (n = 460), we quantified perfluorononanoic (PFNA), perfluorooctane sulfonic (PFOS), perfluorooctanoic (PFOA), methyl-perfluorooctane sulfonamide acetic acid, perfluorohexanesulphonic (PFHxS), perfluorodecanoic (PFDeA), and perfluoroundecanoic (PFUdA) acid concentrations in fasting serum samples at median 17 weeks gestation, along with plasma progesterone, testosterone, and estradiol.
Background: Per- and polyfluoroalkyl substances (PFAS) can disrupt metabolism. Early-to-mid pregnancy is characterized by amplified metabolic processes and inflammation to support maternal adaptations and fetal growth. Thus, we cross-sectionally evaluated whether PFAS are individually and jointly associated with these processes in early-to-mid pregnancy.
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