Coating-Free Culture Medium for Establishing and Maintaining Human Induced Pluripotent Stem Cells.

Cell expansion of human pluripotent stem cells (hPSCs) commonly depends on Matrigel as a coating matrix on two-dimensional (2D) culture plates and 3D microcarriers. However, the xenogenic Matrigel requires sophisticated quality-assurance processes to meet clinical requirements. In this study, we develop an innovative coating-free medium for expanding hPSCs.

Cardiac myofibrillogenesis is spatiotemporally modulated by the molecular chaperone UNC45B.

Sarcomeres are fundamental to cardiac muscle contraction. Their impairment can elicit cardiomyopathies, leading causes of death worldwide. However, the molecular mechanism underlying sarcomere assembly remains obscure.

Effects of Resveratrol on Muscle Inflammation, Energy Utilisation, and Exercise Performance in an Eccentric Contraction Exercise Mouse Model.

Eccentric contraction can easily cause muscle damage and an inflammatory response, which reduces the efficiency of muscle contraction. Resveratrol causes anti-inflammatory effects in muscles, accelerates muscle repair, and promotes exercise performance after contusion recovery. However, whether resveratrol provides the same benefits for sports injuries caused by eccentric contraction is unknown.

Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner.

Background: Mutations in genes encoding sarcomeric proteins lead to failures in sarcomere assembly, the building blocks of contracting muscles, resulting in cardiomyopathies that are a leading cause of morbidity and mortality worldwide. Splicing variants of sarcomeric proteins are crucial at different stages of myofibrillogenesis, accounting for sarcomeric structural integrity. RBM24 (RNA-binding motif protein 24) is known as a tissue-specific splicing regulator that plays an essential role in cardiogenesis.

Polarization dependent solar cell conversion efficiency at oblique incident angles and the corresponding improvement using surface nanoparticle coating.

Despite tremendous efforts on improving the solar cell conversion efficiency at normal incidence, improvement at oblique angles has not been widely addressed, not to mention the corresponding light absorption behaviors at different polarizations. Here we report the characterization of the solar cell conversion efficiency and the spectra of photoresponsivity at various tilted angles. The results show that TM (transverse magnetic) polarized light possesses higher photoresponsivity than TE (transverse electric) polarized light and the difference becomes larger with the incidence angle.

GaN-based LEDs surrounded with a two-dimensional nanohole photonic crystal structure for effective laterally guided mode coupling.

Traditional implementation of photonic crystals (PhCs) on LED light emission surfaces results in weak coupling of light with the PhCs. Here we introduce a GaN-based LED surrounded with a nanohole PhC structure along the mesa edges. The laterally guided modes in the epi-structure can be effectively coupled with the two-dimensional periodic structure.