Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms.

Drug repurposing offers a cost-effective and time-efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising anticancer properties through modulation of key pathways involved in tumor survival, stress adaptation, and therapeutic resistance. This scoping review systematically evaluates the current evidence on sertraline's anticancer mechanisms, efficacy, and translational potential.

Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review.

Background: The human bioaccumulation of micro- and nano-plastics (MNPs) is increasingly being recognised in the aetiology and pathophysiology of human disease.

Objective: This systematic scoping review aims to provide a comprehensive investigation of studies examining the impacts of MNPs on the human cardiovascular system.

Methods: Five databases (PubMed, SCOPUS, CINAHL, Web of Science and EMBASE) were systematically searched.

From Psychiatry to Oncology: Exploring the Anti-Neoplastic Mechanisms of Aripiprazole and Its Potential Use in Cancer Treatment.

Drug repurposing provides a cost-effective and time-saving approach to cancer therapy. Aripiprazole (ARI), a third-generation antipsychotic, has shown potential anticancer properties by modulating pathways central to tumor progression and resistance. This scoping review systematically examines evidence on ARI's anticancer effects, mechanisms of action, and translational potential.