Publications by authors named "Lester Pyatt"
Background: Advanced cell therapies, including chimeric antigen receptor T cell (CAR T cell) therapies, offer novel opportunities for the treatment of advanced blood cancers such as lymphoma and leukaemia. However, as these therapies are relatively new, there is limited information on the experiences of patients and informal caregivers of the treatment which may influence the uptake of these therapies. The aim of this qualitative study was to explore their experiences to facilitate the identification of specific issues that should be addressed to positively impact patient outcomes and experiences of care.
View Article and Find Full Text PDFDevelopment of a conceptual framework for an electronic patient-reported outcome (ePRO) system measuring symptoms and impacts of CAR T-cell therapies in patients with haematological malignancies.
Foram Khatsuria
,
Christel McMullan
,
Olalekan Lee Aiyegbusi
,
Karen L Shaw
,
Roshina Iqbal
,
Lester Pyatt
Lancet Oncol
October 2024
Article Synopsis
- CAR T-cell therapy can cause serious side effects, highlighting the need to understand patient experiences and quality of life through patient-reported outcomes (PROs).
- A study identified 178 relevant symptoms and concepts from 44 articles, which were categorized into four key areas: symptom burden, treatment impact, tolerability, and health-related quality of life.
- A conceptual framework was developed to improve the collection of PRO data, ensuring that patient perspectives are considered in managing treatment for those with blood cancers undergoing CAR T-cell therapy.
Protocol for a mixed-methods study to develop and feasibility test a digital system for the capture of patient-reported outcomes (PROs) in patients receiving chimeric antigen receptor T-cell (CAR-T) therapies (the PRO-CAR-T study).
Sarah E Hughes
,
Christel McMullan
,
Olalekan Lee Aiyegbusi
,
Karen Shaw
,
Francesca Kinsella
,
Lester Pyatt
BMJ Open
March 2024
Article Synopsis
- CAR T-cell therapies are new treatments for blood cancers but can cause serious side effects, so patients need careful monitoring.
- This study is creating a digital system where patients can report their health and symptoms online to help their doctors keep track of their condition.
- The research will involve different groups like patients, doctors, and researchers to test how well this system works and if it's easy for patients to use.