Publications by authors named "Leonard D Genovese"
Article Synopsis
- The HeartMate 3 (HM3) is the only fully magnetically levitated left ventricular assist device (LVAD) available for advanced heart failure patients, but its impact on heart function post-implantation hasn't been fully explored.
- A study comparing HM3 to older LVADs (HeartWare Ventricular Assist Device and HeartMate II) found no significant differences in heart function improvements after implantation.
- The proportion of patients showing significant reverse heart remodeling was similar across all devices, indicating that HM3 technology may be just as effective as older models in supporting heart recovery.
LVAD decommissioning for myocardial recovery: Long-term ventricular remodeling and adverse events.
J Heart Lung Transplant
December 2021
Article Synopsis
- Left ventricular assist devices (LVADs) help improve heart function, and a new method of safely removing the devices while keeping them in place has shown promise, but long-term effects remain uncertain.
- In a study from 2010 to 2020, 29 out of 515 LVAD patients achieved cardiac recovery; 17 underwent a planned decommissioning of the device while monitored over 3 years for heart health outcomes.
- Findings revealed that after one month post-decommissioning, patients experienced a slight decline in heart function, suggesting the need for further research into long-term impacts of LVAD retention.
Article Synopsis
- The study investigates how inflammation from psoriasis, a chronic inflammatory disease, affects cardiovascular disease (CVD) by looking at aortic vascular uptake and aortic wall thickness in patients.
- Researchers found that the severity of psoriasis correlates with greater aortic wall thickness and uptake of a specific imaging marker called 18F-FDG.
- After a year of psoriasis treatment, participants exhibited reductions in both aortic vascular uptake and wall thickness, highlighting potential links between inflammation and early signs of vascular disease.
Article Synopsis
- The study explores the links between chronic stress, as measured by resting amygdala activity, and various cardiovascular health markers in patients with psoriasis, a stress-related inflammatory condition.
- Researchers analyzed data from 164 psoriasis patients and 47 healthy participants, using advanced imaging techniques to assess amygdala and hematopoietic system activity along with cardiovascular indicators.
- Results showed higher amygdala activity in psoriasis patients, correlating with increased hematopoietic activity and subclinical cardiovascular disease markers; treatment of severe psoriasis led to improvements in both skin condition and stress-related measures over one year.