Publications by authors named "Lea Rossillon"
Background: Maintenance treatment with vinorelbine and oral cyclophosphamide (oral-CPM) improves outcome of nonmetastatic high-risk (HR) and very-high risk (VHR) rhabdomyosarcoma (RMS) patients. However, gonadal toxicity of maintenance was not yet investigated.
Methods: The authors focused their analysis on male gonadal toxicity in HR/VHR groups of RMS2005 trial, in France.
Article Synopsis
- Persistent mIBG-positive skeletal metastases after high-dose chemotherapy in high-risk neuroblastoma patients are linked to poor outcomes, prompting an investigation into the effects of irradiation on these metastases.* -
- A retrospective study reviewed 201 patients treated between 2000 and 2020, finding that 15% had persistent skeletal uptake after treatment, with some achieving complete responses, but recurrence was common in areas that were previously affected.* -
- The study suggests that while a minority of patients maintained mIBG positivity post-treatment, managing disease control during therapy remains a significant challenge, complicating efforts to conduct a randomized study on treatment strategies.*