Leveraging mutual information in Variational Autoencoders for improved dimensionality reduction of single-cell RNA sequencing data: The scInfoMaxVAE approach.

Single-cell RNA-seq (scRNA-seq) analysis demands representations that are robust to sparsity and technical noise. We present scInfoMaxVAE, a mutual-information-maximizing variational autoencoder with a zero-inflated count likelihood tailored for scRNA-seq, designed for dimensionality reduction and cell-type classification. We evaluated the model on 12 public scRNA-seq datasets spanning multiple tissues and platforms using a unified pipeline with cell- and gene-level quality control (minimum detected genes), library-size normalization, log-transform, and reference-based cell-type annotation.

The Efficacy of Transplanting Human Umbilical Cord Mesenchymal Stem Cell Sheets in the Treatment of Myocardial Infarction in Mice.

The transplantation of mesenchymal stem cell (MSC) sheets derived from human umbilical cords (hUCs) was investigated in this study as a potential application in treating myocardial infarction (MI). Two groups of hUC-MSC sheets were formed by populating LunaGel, which are 3D scaffolds of photo-crosslinkable gelatin-based hydrogel with two different cell densities. An MI model was created by ligating the left anterior descending coronary artery of healthy BALB/c mice.

Association between maternal depression and risk of infant diarrhea: a systematic review and meta-analysis.

Objective: To systematically review the evidence for an association between maternal depression and the risk of diarrheal illness in infants.

Study Design: This study is a meta-analysis.

Methods: Nine databases were searched systematically for studies that investigated the risk of diarrheal illness in infants born to mothers with depression.