Publications by authors named "Laurent Weingarten"
Easy reversible clustering of gold nanoparticles via pH-Induced assembly of PVP-b-PAA copolymer.
J Colloid Interface Sci
February 2025
The growing demand of novel hybrid organic/inorganic systems with exciting properties has contributed to an increasing need for simplifying production strategies. Here, we report a simple method to obtain controlled three-dimensional hybrid architectures, in particular hybrid supracolloids (hSC), formed by gold nanoparticles and a double hydrophilic block copolymer, specifically the poly(acrylic acid)-block-poly(N-vinyl-2-pyrrolidone) (PAA-b-PVP), directly in aqueous medium. The ubiquitous pH-sensitive poly(acrylic acid) (PAA) block initiates the assembly through pH changes, while the poly(N-vinyl-2-pyrrolidone) block assures the close affinity with the AuNPs.
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- Food hypersensitivities are on the rise in developed countries, with food-grade titanium dioxide (fg-TiO) suspected as a contributing factor due to its nanoparticle (NP) composition and immunomodulatory effects.
- In a study involving pregnant mice fed a TiO-enriched diet, researchers found that the dietary NPs passed to the fetus, resulting in their offspring developing a breakdown in oral tolerance (OT) to ovalbumin (OVA), indicated by increased anti-OVA IgG levels when they became adults.
- Additionally, adult mice directly exposed to fg-TiO also exhibited OT failure and intestinal inflammation upon OVA challenge, showing that long-term exposure disrupts key anti-inflammatory cytokines essential for maintaining OT
The whitening and opacifying agent titanium dioxide (TiO) is used worldwide in various foodstuffs, toothpastes and pharmaceutical tablets. Its use as a food additive (E171 in EU) has raised concerns for human health. Although the buccal mucosa is the first area exposed, oral transmucosal passage of TiO particles has not been documented.
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