A lanthanum bromide detector of runaway electrons for TCV.

The safe control and dissipation of Runaway Electrons (REs) generated in tokamak plasmas is vital for the operation of future fusion reactors. Measuring the evolution of RE energy in tokamaks is important for understanding their generation, transport, and termination. A new gamma ray spectrometer using a 2″ × 2″ cylindrical, cerium doped lanthanum bromide (LaBr3:Ce) scintillator coupled to a fast photomultiplier tube was developed for studying runaway electrons on the Tokamak à Configuration Variable (TCV).

Bracing for the worst? Real-time scanxiety and uncertainty management during cancer surveillance.

Objectives: "Scanxiety" is a common and distressing experience that can negatively impact quality of life after completing cancer treatment, yet little research has investigated risk factors for scanxiety as it emerges in real time. This study used an ecological momentary assessment design to examine how uncertainty management strategies predict the experience of "scanxiety," operationalized via self-reported fear of cancer recurrence (FCR) in the days before, on, and after a routine surveillance scan or test.

Method: Adolescent and young adult survivors of childhood cancer ( = 55, = 17.

Scheffersomyces spartinae Fungemia among Pediatric Patients, Pakistan, 2020-2024.

Prevalence of emerging fungal infections is increasing, particularly among immunocompromised persons, children, and older persons. We report 108 cases of Scheffersomyces spartinae infection in pediatric patients from Karachi and other cities in Pakistan, of which 107 were identified from blood cultures. Cultures were initially misidentified as Clavispora lusitaniae by a biochemical assay before speciation as S.

Targeting Siglec-10/α3β1 Integrin Interactions Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer.

Tumor-associated macrophages (TAMs) in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) exhibit immunosuppressive phenotypes and impaired phagocytic activity, facilitating tumor progression and immune evasion. Here, we identify integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for Siglec-10, an inhibitory glyco-immune checkpoint receptor highly expressed on TAMs in PDAC. The interaction between Siglec-10 on TAMs and α3β1 on PDAC cells suppresses macrophage-mediated phagocytosis, thereby promoting immune evasion.