Demethoxycurcumin induces apoptosis and reduces cell migration by affecting AKT/mTOR-dependent autophagy in human glioma U87MG and T98G cell lines.

Background: Standard treatment for glioblastoma includes chemotherapy, alkylating agents such as temozolomide (TMZ); however, MGMT resistance leads to recurrence. Demethoxycurcumin (DMC) has been reported to inhibit cancer cell growth, induce apoptosis, and prevent metastasis in different cancer models. We investigated the DMC-induced apoptosis and autophagy via inhibition of the AKT/mTOR pathway in human glioma U87MG and T98G cell lines.

Methods for the analysis of leukemic infiltration within cerebrospinal fluid in acute lymphoblastic leukemia-a systematic review.

Central nervous system (CNS) involvement in acute lymphoblastic leukemia (ALL) is associated with a poor prognosis, making its accurate detection vital for treatment planning. This systematic review critically examines the role of conventional cytomorphology (CC) and multiparameter flow cytometry (FC) in analyzing cerebrospinal fluid in acute lymphoblastic leukemia cases. While CC remains the gold standard, its sensitivity is limited, particularly in cases with low cell counts.

Assessing the Practice of Infection Control Among Dialysis Staff in Dialysis Centers in Northeast India.

Background: Chronic kidney disease patients on maintenance hemodialysis have multiple co-morbidities and high risk of infections. This study was conducted to assess the idea and practice of infection control measures in dialysis units in northeast India.

Materials And Methods: This observational descriptive study was conducted among the participants of the 5 hemodialysis technician's conference, held at Guwahati on 29 and 30 October 2022.

Synthesis, Optimization and Characterization of Cyanobacteria-Derived Silver Nanoparticles for Enhancing Rice Seed Germination.

The rapid advancement of nanotechnology has paved the way for innovative strategies in sustainable agriculture, particularly through the development and use of metallic nanoparticles. Among these, silver nanoparticles (Ag NPs) have garnered significant attention due to their distinct physicochemical characteristics. The current research illustrates the environmentally friendly production of Ag NPs by aqueous extracts of two cyanobacterial strains Westiellopsis ramosa and Nostoc commune.

Nanotechnology Based Topical Insulin Delivery System: Promising Role in Diabetic Wound Healing.

Diabetes is a chronic metabolic disorder characterised by elevated blood glucose levels, leading to widespread systemic and localised complications, including weakened wound healing. Diabetic wounds, particularly diabetic foot ulcers (DFUs), are related to delayed healing, chronic inflammation, and increased risk of amputation. Key pathological factors include hyperglycemia-induced oxidative stress, neuropathy, immune dysfunction, and impaired angiogenesis.