Publications by authors named "L Ramachandra"
Article Synopsis
- There is an urgent need for better immunization strategies against tuberculosis (TB) than the current BCG vaccine, as clinical development is limited by not having clear immune correlates of protection (CoPs).
- Two phase 2b clinical trials have been conducted, one examining BCG re-vaccination in adolescents and the other focusing on the M72/AS01 vaccine in adults, both showing partial protection against TB infections.
- Collaborative research programs aim to identify CoPs against TB using advanced technologies and international expertise, with defined hypotheses on immune responses, a strategic data analysis framework, and plans for exploratory analyses to create new hypotheses.
MicroRNAs (miRNAs) play a significant role in nuclear and mitochondrial anterograde and retrograde signaling. Most of the miRNAs found inside mitochondria are encoded in the nuclear genome, with a few mitochondrial genome-encoded non-coding RNAs having been reported. In this study, we have identified 13 mitochondrial genome-encoded microRNAs (mitomiRs), which were differentially expressed in breast cancer cell lines (MCF-7, MDA-MB-468 and MDA-MB-231), non-malignant breast epithelial cell line (MCF-10A), and normal and breast cancer tissue specimens.
View Article and Find Full Text PDFBackground Information: Excessive angiogenesis characterized by leaky, tortuous, and chaotic vasculature is one of the hallmarks of cancers and is significantly correlated to poor prognosis. Disorganized angiogenesis leads to poor perfusion of anti-cancer drugs and limits access to immune cells. Hence, impeding angiogenesis is one of the attractive therapeutic targets to inhibit progression and metastasis in several solid tumors including breast.
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