Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel-Treated Participants.

Black individuals undergoing percutaneous coronary intervention (PCI) experience higher rates of major adverse cardiovascular events (MACE) than non-Black individuals. This study assessed the racial differences in platelet reactivity and clinical outcomes among clopidogrel-treated participants. Two cohorts were analyzed.

The Role of Radiotherapy in MPNST and the Impact of NF1 Status on Outcomes: Insights From A Multicenter Cohort Study.

Background: Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are rare, aggressive sarcomas, with 40% associated with neurofibromatosis type 1 (NF1). Surgical excision is the main treatment for localized disease, however, local recurrence (LR) remains high. Radiotherapy (RTx) is increasingly used to enhance local control in STS, but its use remains controversial due to the potential for increased major wound complications and an increased risk of secondary malignancies in NF1 patients.

Short-term morbidity following primary closure, skin grafting and flap reconstruction after surgical resection of extremity soft-tissue sarcomas: Pushing the limits of limb preservation.

Introduction: Understanding short-term morbidity following extremity soft-tissue sarcoma (ESTS) treatment remains complex due to diverse findings and the absence of a standardized wound complication assessment. This retrospective cohort study evaluated short-term morbidity following primary closure, skin grafting, and flap reconstruction.

Materials And Methods: All ESTS patients treated in a sarcoma center in the Netherlands from 1-1-2010 until 1-8-2022 were included.

Pandemic driven preoperative moderate hypofractionated radiotherapy for soft tissue sarcomas.

Purpose: Moderate hypofractionation was adopted to reduce hospital visits during the COVID-19 pandemic aiming to maintain treatment efficacy for soft tissue sarcoma (STS) patients, shifting preoperative schedules from 25 fractions of 2 Gy to 14-15 fractions of 3 Gy. This study evaluates the clinical implications and outcomes of this schedule, focusing on wound complications, radiation toxicity, local tumour control, and distant metastases.

Patients And Methods: Data was collected from patients treated between 01 and 01-2020 and 31-12-2023.