Automated strength-interval curve generation using actors.

Background And Objective: Strength-interval (SI) curves are used by physiologists to quantify the response of excitable tissue as a function of the strength and timing of an electrical stimulus. In the context of cardiac electrophysiology, SI curves characterize the refractoriness of cardiac tissue as a function of inter-stimulus interval length. Although conventionally collected experimentally, this type of information can now more conveniently be obtained through computational simulation.

Accurate and Efficient Numerical Simulation of Land Models Using SUMMA With SUNDIALS.

Numerical simulation of land models without error control can be highly inaccurate. We present the incorporation of the Suite of Nonlinear and Differential-Algebraic Equation Solvers (SUNDIALS) package to solve the equations that simulate thermodynamics and hydrologic processes in the Structure for Unifying Multiple Modeling Alternatives (SUMMA) land model. The algorithmic features of SUNDIALS, such as error estimation and adaptive order and step-size control, result in a SUMMA-SUNDIALS model that delivers substantially improved accuracy and relative computational efficiency compared to integration with the previous SUMMA model, which uses the low-order backward Euler method with no rigorous error control.