Cost-effectiveness analysis of pharmacogenetic-guided warfarin dosing in Thailand.

Introduction: Pharmacogenetic (PGx) test is a useful tool for guiding physician on an initiation of an optimal warfarin dose. To implement of such strategy, the evidence on the economic value is needed. This study aimed to determine the cost-effectiveness of PGx-guided warfarin dosing compared with usual care (UC).

Assessing key model parameters for economic evaluation of pandemic influenza interventions: the data source matters.

Background: In our previous systematic review of economic evaluations of pandemic influenza interventions, five model parameters, namely probability of pandemic, duration of pandemic, severity, attack rate, and intervention efficacy, were not only consistently used in all studies but also considered important by authors.

Objectives: Because these parameters originated from sources of varying quality ranging from experimental studies to expert opinion, this study aims to analyze the variation in values used according to sources of information across studies.

Methods: An analysis of estimated values of key parameters for economic modeling was performed against their different data sources, following the standard hierarchy of evidence.