circ_BICD2 acts as a ceRNA to promote tumor progression and Warburg effect in oral squamous cell carcinoma by sponging miR-107 to enhance HK2.

Numerous studies have proved that the Warburg effect serves a vital role involved in regulating the progression of malignant tumors. Previous studies confirmed that circRNAs act as a novel biomarker for diagnostic and therapeutic in various tumors. However, the functional role and mechanism of circ_BICD2 for the regulation of tumor growth and metastasis in oral squamous cell carcinoma (OSCC) via mediating the Warburg effect are largely unknown.

[Effects of enzyme inhibitors on the pigment synthesis in Monascus anka].

Monascus pigment is a natural, safe pigment and preservative. Six inhibitors of key enzymes from three metabolic pathways were chosen according to databases, and were used in basic medium to study their effects on the pigment synthesis in Monascus anka strain M5034. Trimethylamine, inhibitor of shikimic acid pathways, and anthranilic acid and 3,4-dihydroxybenzoic acid, inhibitors of mevalonic acid pathways, had no effects on the pigment biosynthesis.